Provectus Pharmaceuticals, Inc.
                         7327 Oak Ridge Highway, Suite A
                           Knoxville, Tennessee 37931
                                 (865) 769-4011




                                February 11, 2004

U.S. Securities and Exchange Commission
450 Fifth Street, N.W., Judiciary Plaza
Washington, D.C. 20549
Attn:  Mr. Jeffrey P. Riedler, Assistant Director

                                                                       VIA EDGAR

         Re:      Provectus Pharmaceuticals, Inc.
                  Registration Statement of Form S-3 Filed January 16, 2004
                  Registration No. 333-111982

Ladies and Gentlemen:

     Provectus  Pharmaceuticals,  Inc., a Nevada corporation (the "Registrant"),
hereby  requests,  pursuant to Rule  477(a) of the  Securities  Act of 1933,  as
amended  (the  "Act"),   that  the  Securities  and  Exchange   Commission  (the
"Commission")  consent  to  the  withdrawal  of  the  Registrant's  Registration
Statement on Form S-3 (Registration No. 333-111982),  which previously was filed
with the Commission on January 16, 2004 (the "Registration Statement").

     The Registrant is requesting the withdrawal of the  Registration  Statement
based  on the  Staff  of  the  Commission's  views  regarding  the  Registrant's
eligibility to use Form S-3.

     The  Registration   Statement  has  not  been  declared  effective  by  the
Commission and no securities  have been sold under the  Registration  Statement.
The  Registrant  requests,  in accordance  with Rule 457(p) of the Act, that all
fees paid to the  Commission in connection  with the filing of the  Registration
Statement be credited to the Registrant's account for future use.

     Please direct any questions  regarding  this filing to the  undersigned  at
865-769-4011,   H.  Craig   Dees   (865-769-4011)   or   Michael   S.   McKinney
(423-928-0181), counsel to the Registrant.

                                  Very truly yours,

                                  /s/ Timothy C. Scott

                                  Timothy C. Scott
                                  President
                                  Provectus Pharmaceuticals, Inc.