Filed Pursuant to Rule 424(b)(3)
                                                             File No. 333-115393

                              PROSPECTUS SUPPLEMENT
                       (TO PROSPECTUS DATED MAY 21, 2004)

                            IRIS INTERNATIONAL, INC.

                     Up to 2,571,975 shares of Common Stock

         Our common  stock is  currently  quoted on the Nasdaq  National  Market
under the symbol  "IRIS." On June 6, 2005,  the last  reported sale price of our
common stock on the Nasdaq National Market was $18.10 per share.

         This prospectus  supplement  supplements  the prospectus  dated May 21,
2004  relating  to the  offer  and sale  from  time to time by  certain  selling
stockholders of up to 2,571,975 shares of our common stock.

         This  prospectus  supplement  should  be read in  conjunction  with the
prospectus.  This  prospectus  supplement  is  qualified  by  reference  to  the
prospectus,  except  to the  extent  that  the  information  in this  prospectus
supplement supersedes the information contained in the prospectus.

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         On May 11, 2005,  Oppenheimer & Co. Inc., a selling  stockholder listed
in the  prospectus,  transferred  warrants to purchase  an  aggregate  of 64,300
shares  of our  common  stock to each of the other  parties  listed in the table
below. The warrants transferred by Oppenheimer & Co. Inc. have an exercise price
of $7.80 per share and are exercisable  immediately  through and including April
29,  2009  or,  if such  date  does not fall on a  business  day,  then the next
business day.  Certain of these  transferees  have  exercised  their warrants to
purchase shares of common stock and the table below reports,  in such cases, the
common stock  beneficially  owned as of the date of this prospectus  supplement.
The  information  appearing  under the  heading  "Selling  Stockholders"  in the
prospectus is hereby amended by the addition or substitution,  as applicable, of
the following:



                                              PERCENT OF
                           NUMBER OF          OUTSTANDING       NUMBER OF         NUMBER OF          PERCENT OF
                           SHARES OF           SHARES OF        SHARES OF         SHARES OF           SHARES OF
                         COMMON STOCK        COMMON STOCK     COMMON STOCK      COMMON STOCK        COMMON STOCK
                         BENEFICIALLY        BENEFICIALLY     TO BE OFFERED     BENEFICIALLY        BENEFICIALLY
NAME OF SELLING           OWNED PRIOR         OWNED PRIOR   PURSUANT TO THIS     OWNED AFTER         OWNED AFTER
STOCKHOLDER               TO OFFERING         TO OFFERING    PROSPECTUS (1)   THE OFFERING (2)     THE OFFERING (2)
------------------------------------------------------------------------------------------------------------------
                                                                                          
Oppenheimer & Co. Inc. (3)    31,716              *              31,716                0                 *
Frank Kee Colen (4)           17,780              *              17,780                0                 *
Yvonne Briggs (5)              9,455              *               9,455                0                 *
Robert Powers (6)              6,125              *               6,125                0                 *
Henry Williams                 4,585              *               4,585                0                 *
Chris Hagar                    3,235              *               3,235                0                 *
Stanley Stern (6)              1,000              *               1,000                0                 *
Andrew Kaminsky                  578              *                 578                0                 *
Corey Dorzek                     554              *                 554                0                 *
Zubin Mory                       275              *                 275                0                 *
----------

*        Represents less than One Percent of the outstanding shares.
(1)      Includes  the  shares of common  stock  which are the  subject  of this
         Prospectus.
(2)      Assumes that all shares being offered by each selling stockholder under
         this  prospectus  are sold,  that the selling  stockholder  acquires no
         additional  shares  of  common  stock  before  the  completion  of this
         offering,  and that the  selling  stockholder  disposes of no shares of
         common stock other than those offered under this prospectus.
(3)      Albert G. Lowenthal,  Robert M. Neuhoff and Dennis P. McNamara exercise
         voting and  investment  authority over the shares held by Oppenheimer &
         Co. Inc.
(4)      Consists of 6,700 shares of common stock  issuable upon the exercise of
         warrants by the selling stockholder.
(5)      Consists of 3,100 shares of common stock  issuable upon the exercise of
         warrants by the selling stockholder.
(6)      Consists  of shares of  common  stock  issuable  upon the  exercise  of
         warrants by the selling stockholder.



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             The date of this prospectus supplement is June 7, 2005