UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM S-8

                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933


                            IRIS INTERNATIONAL, INC.
             (Exact Name of Registrant as Specified in Its Charter)


            DELAWARE                                           94-2579751
  (State or Other Jurisdiction of                           (I.R.S. Employer
   Incorporation or Organization)                          Identification No.)


           9172 ETON AVENUE
            CHATSWORTH, CA                                        91311
 (Address of Principal Executive Offices)                       (Zip Code)


               IRIS INTERNATIONAL, INC. 2007 STOCK INCENTIVE PLAN
                            (Full Title of the Plans)

                    CESAR M. GARCIA, CHIEF EXECUTIVE OFFICER
                            IRIS INTERNATIONAL, INC.
                                9172 ETON AVENUE
                              CHATSWORTH, CA 91311
                     (Name and Address of Agent for Service)

                                 (818) 709-1244
          (Telephone Number, Including Area Code, of Agent for Service)

                                   Copies to:
                               JOHN MCILVERY, ESQ.
                         STUBBS ALDERTON & MARKILES, LLP
                       15260 VENTURA BOULEVARD, 20TH FLOOR
                             SHERMAN OAKS, CA 91403


                         CALCULATION OF REGISTRATION FEE

============================= ================ ================== ==================== ==================
     Title of Each Class                        Proposed Maximum    Proposed Maximum
        of Securities           Amount To Be     Offering Price    Aggregate Offering      Amount of
       To Be Registered        Registered (1)     Per Share (2)         Price (2)       Registration Fee
----------------------------- ---------------- ------------------ -------------------- ------------------
                                                                                
Common Stock, par value
   $.01 per share............    1,750,000           $16.18            $28,315,000          $869.28
============================= ================ ================== ==================== ==================

(1)      Pursuant to Rule 416 under the  Securities Act of 1933, as amended (the
         "Securities  Act"),  this  Registration   Statement  also  covers  such
         additional  shares as may  hereinafter  be offered or issued to prevent
         dilution  resulting  from  stock  splits,  stock  dividends  or similar
         transactions effected without the receipt of consideration.
(2)      Estimated  solely for the purpose of calculating the  registration  fee
         pursuant to Rule 457(h) under the  Securities  Act of 1933, as amended,
         based on a per share  price of $16.18,  the average of the high and low
         reported  sales prices of the  Registrant's  common stock on the NASDAQ
         Global Market on August 16, 2007.





--------------------------------------------------------------------------------
                                EXPLANATORY NOTE

            This registration statement on Form S-8 of IRIS International,  Inc.
has been  prepared in  accordance  with the  requirements  of Form S-8 under the
Securities  Act of 1933,  as amended,  with respect to  1,750,000  shares of our
common stock,  par value $0.01 per share  issuable to  participants  in the IRIS
International, Inc. 2007 Stock Incentive Plan.

--------------------------------------------------------------------------------

                                     PART I

              INFORMATION REQUIRED IN THE SECTION 10(A) PROSPECTUS

         The document(s)  containing the information specified in Part I will be
sent or given to participants as specified by Rule 428(b)(1). Such documents are
not being  filed with the  Securities  and  Exchange  Commission  ("Commission")
either as part of this  Registration  Statement or as prospectuses or prospectus
supplements pursuant to Rule 424. These documents and the documents incorporated
by reference  in this  Registration  Statement  pursuant to Item 3 of Part II of
this Form,  taken together,  constitute a prospectus that meets the requirements
of Section 10(a) of the Securities Act of 1933, as amended.


                                       2



                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3.  INCORPORATION OF DOCUMENTS BY REFERENCE

         The following  documents  previously  filed by the Registrant  with the
Securities  and  Exchange  Commission  are  incorporated  in  this  Registration
Statement by reference:

         o        The  Registrant's  Annual  Report on Form 10-K for the  fiscal
                  year ended  December  31,  2006,  as amended on April 30, 2007
                  (File No. 001-11181);

         o        The  Registrant's  Quarterly  Reports  on  Form  10-Q  for the
                  quarterly period ended March 31, 2007 (File No. 001-11181) and
                  June 30, 2007 (File No. 001-11181);

         o        The Registrant's Current Reports on Form 8-K filed on March 7,
                  2007  (File  No.   001-11181),   April  13,   2007  (File  No.
                  001-11181),  May 11, 2007 (File No. 001-11181),  July 18, 2007
                  (File No. 001-11181),  August 8, 2007 (File No. 001-11181) and
                  August 13, 2007 (File No. 001-11181); and

         o        The description of the Registrant's  common stock contained in
                  our  registration  statement on Form 8-A filed with the SEC on
                  June 3, 1981,  including any amendment or report filed for the
                  purpose of updating this description.

         All  documents  filed by the  Registrant  pursuant to  Sections  13(a),
13(c),  14 or  15(d)  of the  Securities  Exchange  Act  of  1934,  as  amended,
subsequent to the date of this Registration Statement and prior to the filing of
a  post-effective  amendment which indicates that all securities  offered hereby
have been sold or which deregisters all securities then remaining unsold,  shall
be deemed to be incorporated by reference into this  Registration  Statement and
to be a part hereof from the date of filing of such documents.

ITEM 4.  DESCRIPTION OF SECURITIES.

         Not applicable.

ITEM 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL.

         Not applicable.

ITEM 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS.

         Section 145 of the Delaware  General  Corporation  Law provides  that a
corporation may indemnify  directors and officers as well as other employees and
individuals against expenses,  including attorneys' fees,  judgments,  fines and
amounts paid in  settlement  in  connection  with  specified  actions,  suits or
proceedings,  whether civil,  criminal,  administrative or investigative  (other
than an action by or in the right of the corporation or a derivative action), if
they acted in good faith and in a manner  they  reasonably  believed to be in or
not opposed to the best  interests of the  corporation  and, with respect to any
criminal action or proceedings, had no reasonable cause to believe their conduct
was unlawful.

         A similar  standard is applicable  in the case of  derivative  actions,
except that indemnification only extends to expenses (including attorneys' fees)
actually and reasonably incurred in connection with the defense or settlement of
such action,  and the statute  requires court  approval  before there can be any
indemnification  where the person seeking  indemnification has been found liable
to the  corporation.  The statute  provides  that it is not  exclusive  of other
indemnification   that  may  be  granted  by  a  corporation's   Certificate  of
Incorporation,  Bylaws, disinterested director vote, stockholder vote, agreement
or otherwise.


                                       3



         As permitted by Section 145 of the Delaware  General  Corporation  Law,
Article  VIII of the  Registrant's  Certificate  of  Incorporation,  as amended,
provides:

            "The  corporation  shall to the fullest extent  permitted by Section
            145 of the Delaware  General  Corporation  Law indemnify all persons
            whom it may indemnify pursuant thereto."

         The  Registrant's  Bylaws provide for  indemnification  of officers and
directors  to the fullest  extent  permitted by Delaware  law. In addition,  the
Registrant  has, and intends in the future to enter into,  agreements to provide
indemnification  for  directors and officers in addition to that provided for in
the Bylaws.

         In  addition  to  the  indemnification  required  in  the  Registrant's
Certificate  of  Incorporation  and Bylaws,  the  Registrant  has  entered  into
indemnity  agreements  with each of its current  officers and  directors.  These
agreements  provide for the  indemnification  of the Registrant's  directors and
officers for all reasonable expenses and liabilities incurred in connection with
any action or  proceeding  brought  against them by reason of the fact that they
are  or  were  the   Registrant's   agents.   The   Registrant   believes  these
indemnification  provisions  and  agreements are necessary to attract and retain
qualified directors and officers.

         The  Registrant  maintains  insurance  on behalf of any person who is a
director or officer against any loss arising from any claim asserted against any
of them and expense incurred by any of them in any capacity,  subject to certain
exclusions.

ITEM 7.  EXEMPTION FROM REGISTRATION.

         Not applicable.

ITEM 8.  EXHIBITS.

         The  following   exhibits  are  filed  as  part  of  this  Registration
Statement:

EXHIBIT
  NO.    EXHIBIT DESCRIPTION
-------  -------------------

4.1      Certificate of Incorporation, as amended. (1)
4.1(b)   Certificate  of  Designations,  Preferences  and  Rights  of  Series  C
         Preferred. (2)
4.1(c)   Certificate of Ownership and Merger. (3)
4.2      Amended and Restated Bylaws. (4)
4.2(b)   Amendment to Amended and Restated  Bylaws of Iris  International,  Inc.
         (5)
4.3      IRIS International, Inc. 2007 Stock Incentive Plan
5.1      Opinion of Stubbs Alderton & Markiles, LLP
23.1     Consent of BDO Seidman, LLP
23.2     Consent of Stubbs Alderton & Markiles, LLP (included in Exhibit 5.1).
24.1     Power  of  Attorney  (included  as part of the  Signature  Page of this
         Registration Statement).

(1)  Incorporated  by reference  to the Current  Report on Form 8-K dated August
     13,  1987 and the  Quarterly  Report  on Form  10-Q for the  quarter  ended
     September 30, 1993.
(2)  Incorporated by reference to Exhibit 99.2 to the Current Report on Form 8-K
     dated January 26, 2000.
(3)  Incorporated  by reference to Exhibit  3.1(d) to the Annual  Report on Form
     10-K for the year ended December 31, 2003.
(4)  Incorporated  by reference to Exhibit 3.2 to the Annual Report on Form 10-K
     for the year ended December 31, 2003.
(5)  Incorporated  by reference to Exhibit 3.2 to the Current Report on Form 8-K
     dated July 18, 2007


                                       4



ITEM 9.  UNDERTAKINGS.

         (a) The undersigned Registrant hereby undertakes:

                  (1) To file,  during any  period in which  offers or sales are
being made, a post-effective amendment to this Registration Statement:

                       (i) To include any propectus required by section 10(a)(3)
of the Securities Act of
1933;

                       (ii) To  reflect  in the  prospectus  any facts or events
arising after the effective
date of the registration statement (or the most recent post-effective  amendment
thereof) which, individually or in the aggregate, represent a fundamental change
in the information set forth in the registration statement.  Notwithstanding the
foregoing,  any  increase or decrease  in volume of  securities  offered (if the
total  dollar  value of  securities  offered  would not  exceed  that  which was
registered) and any deviation from the low or high end of the estimated  maximum
offering  range  may be  reflected  in the  form of  prospectus  filed  with the
Commission  pursuant to Rule 424(b) if, in the aggregate,  the changes in volume
and price  represent no more than 20% change in the maximum  aggregate  offering
price set forth in the "Calculation of Registration  Fee" table in the effective
registration statement.

                       (iii) To include any material information with respect to
the plan of distribution not previously disclosed in the registration  statement
or any material change to such information in the registration statement;

                  PROVIDED, HOWEVER, that paragraphs (a)(1)(i) and (a)(1)(ii) do
not  apply  if the  information  required  to be  included  in a  post-effective
amendment by those  paragraphs  is contained in periodic  reports  filed with or
furnished to the Commission by the Registrant  pursuant to section 13 or section
15(d) of the Exchange Act that are incorporated by reference in the Registration
Statement.

                  (2) That, for the purpose of determining  any liability  under
the Securities Act of 1933, each such  post-effective  amendment shall be deemed
to be a new registration  statement  relating to the securities offered therein,
and the  offering  of such  securities  at that  time  shall be deemed to be the
initial bona fide offering thereof.

                  (3) To remove from  registration by means of a  post-effective
amendment  any of the  securities  being  registered  which remain unsold at the
termination of the offering.

         (b) The undersigned  Registrant hereby undertakes that, for purposes of
determining  any liability  under the Securities Act of 1933, each filing of the
registrant's  annual  report  pursuant to section  13(a) or section 15(d) of the
Securities  Exchange  Act of 1934  (and,  where  applicable,  each  filing of an
employee  benefit  plan's  annual  report  pursuant  to  section  15(d)  of  the
Securities  Exchange  Act of 1934)  that is  incorporated  by  reference  in the
registration  statement  shall  be  deemed  to be a new  registration  statement
relating to the securities offered therein,  and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.

         (c)  Insofar  as  indemnification  for  liabilities  arising  under the
Securities  Act of 1933 may be permitted to directors,  officers or  controlling
persons of the Registrant  pursuant to the foregoing  provisions,  or otherwise,
the  Registrant  has been  advised  that in the  opinion of the  Securities  and
Exchange  Commission such  indemnification is against public policy as expressed
in the Securities  Act of 1933 and is,  therefore,  unenforceable.  In the event
that a claim  for  indemnification  against  such  liabilities  (other  than the
payment by the Registrant of expenses incurred or paid by a director, officer or
controlling  person of the Registrant in the  successful  defense of any action,
suit or proceeding) is asserted by such director,  officer or controlling person
in connection with the securities being registered,  the Registrant will, unless
in the  opinion  of its  counsel  the matter  has been  settled  by  controlling
precedent,  submit to a court of appropriate  jurisdiction  the question whether
such  indemnification  by it is  against  public  policy  as  expressed  in  the
Securities  Act of 1933 and will be governed by the final  adjudication  of such
issue.


                                       5



                                   SIGNATURES

          Pursuant  to the  requirements  of the  Securities  Act  of  1933,  as
amended, the Registrant certifies that it has reasonable grounds to believe that
it meets all of the requirements for filing on Form S-8 and has duly caused this
registration statement to be signed on its behalf by the undersigned,  thereunto
duly authorized, in the City of Chatsworth, California on August 22, 2007.

                                      IRIS INTERNATIONAL, INC.
                                      (Registrant)

                                      By:    /S/ CESAR M. GARCIA
                                           -------------------------------------
                                           Cesar M. Garcia
                                           President and Chief Executive Officer


                                       6



                                POWER OF ATTORNEY

          Each person whose  signature  appears below  constitutes  and appoints
Cesar M.  Garcia as his true and  lawful  attorney-in-fact  and agent  with full
power of substitution and resubstitution, for him and his name, place and stead,
in  any  and  all  capacities,   to  sign  any  or  all  amendments   (including
post-effective  amendments)  to this  Registration  Statement  and to file a new
registration  statement  under  Rule  461 or  Instruction  E of Form  S-8 of the
Securities  Act of 1933,  as amended,  and to file the same,  with all  exhibits
thereto,  and other documents in connection  therewith,  with the Securities and
Exchange Commission, granting unto said attorney-in-fact and agents, and each of
them,  full power and  authority  to do and perform each and every act and thing
requisite and necessary to be done in and about the  foregoing,  as fully to all
intents and  purposes as he might or could do in person,  hereby  ratifying  and
confirming  all that said  attorney-in-fact  and agents,  or either of them,  or
their substitutes, may lawfully do or cause to be done by virtue hereof.

         Pursuant to the requirements of the Securities Act of 1933, as amended,
this  registration  statement has been signed below by the following  persons in
the capacities and on the date indicated.

SIGNATURE                     TITLE                                  DATE
---------                     -----                                  ----

/S/ CESAR M. GARCIA           President and Chief Executive      August 22, 2007
-------------------------     Officer (Principal Executive
Cesar M. Garcia               Officer), Director and
                              Corporate Secretary

/S/ PETER DONATO              Chief Financial Officer            August 22, 2007
-------------------------     (Principal Financial and
Peter Donato                  Accounting Officer)

/S/ RICHARD H. WILLIAMS       Director                           August 22, 2007
-------------------------
Richard H. Williams

/S/ STEVEN M. BESBECK         Director                           August 22, 2007
-------------------------
teven M. Besbeck

/S/ THOMAS H. ADAMS           Director                           August 22, 2007
-------------------------
Thomas H. Adams

/S/ RICHARD G. NADEAU         Director                           August 22, 2007
-------------------------
Richard G. Nadeau

/S/ MICHAEL D. MATTE          Director                           August 22, 2007
-------------------------
Michael D. Matte

/S/ STEPHEN E. WASSERMAN      Director                           August 22, 2007
-------------------------
Stephen E. Wasserman


                                       7



                                  EXHIBIT INDEX


EXHIBIT
  NO.    EXHIBIT DESCRIPTION
-------  -------------------

4.1      Certificate of Incorporation, as amended. (1)
4.1(b)   Certificate  of  Designations,  Preferences  and  Rights  of  Series  C
         Preferred. (2)
4.1(c)   Certificate of Ownership and Merger. (3)
4.2      Amended and Restated Bylaws. (4)
4.2(b)   Amendment to Amended and Restated  Bylaws of Iris  International,  Inc.
         (5)
4.3      IRIS International, Inc. 2007 Stock Incentive Plan
5.1      Opinion of Stubbs Alderton & Markiles, LLP
23.1     Consent of BDO Seidman, LLP
23.2     Consent of Stubbs Alderton & Markiles, LLP (included in Exhibit 5.1).
24.1     Power  of  Attorney  (included  as part of the  Signature  Page of this
         Registration Statement).

(1)  Incorporated  by reference  to the Current  Report on Form 8-K dated August
     13,  1987 and the  Quarterly  Report  on Form  10-Q for the  quarter  ended
     September 30, 1993.
(2)  Incorporated by reference to Exhibit 99.2 to the Current Report on Form 8-K
     dated January 26, 2000.
(3)  Incorporated  by reference to Exhibit  3.1(d) to the Annual  Report on Form
     10-K for the year ended December 31, 2003.
(4)  Incorporated  by reference to Exhibit 3.2 to the Annual Report on Form 10-K
     for the year ended December 31, 2003.
(5)  Incorporated  by reference to Exhibit 3.2 to the Current Report on Form 8-K
     dated July 18, 2007


                                       8