UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

                                 Date of Report
                       (Date of Earliest Event Reported):
                                  June 30, 2008


                            IRIS INTERNATIONAL, INC.
             (Exact name of registrant as specified in its charter)


         Delaware                       1-11181                   94-2579751
(State or other jurisdiction         (Commission              (I.R.S. Employer
     of incorporation)               File Number)            Identification No.)


                                9172 Eton Avenue
                              Chatsworth, CA 91311
                (Address of Principal Executive Offices/Zip Code)


                                 (818) 709-1244
              (Registrant's telephone number, including area code)


         Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

[_]      Written  communications  pursuant to Rule 425 under the  Securities Act
         (17 CFR 230.425)

[_]      Soliciting  material pursuant to Rule 14a-12 under the Exchange Act (17
         CFR 240.14a-12)

[_]      Pre-commencement  communications  pursuant to Rule  14d-2(b)  under the
         Exchange ct (17 CFR 240.14d-2(B))

[_]      Pre-commencement  communications  pursuant to Rule 13e-4(c))  under the
         Exchange Act (17 CFR 240.13e-4c))





Item 1.01. Entry into a Material Definitive Agreement.

Item 2.03. Creation of a Direct Financial Obligation or an Obligation under an
Off-Balance Sheet Arrangement of a Registrant.

         We are a party to (i) that certain Business Loan Agreement, dated March
24, 2006,  with  California  Bank & Trust (the "Bank"),  as amended to date, and
related  agreements  with  respect to a $6.5 million  loan  facility  (the "$6.5
Million Facility"),  and (ii) that certain Business Loan Agreement,  dated March
24, 2006, with the Bank, as amended to date, and related agreements with respect
to a $10.0 million loan facility (the "$10.0  Million  Facility"  and,  together
with the $6.5  Million  Facility,  the  "Loan  Facilities").  We do not have any
indebtedness outstanding under either of the Loan Facilities.

         On June 30,  2008,  we and the Bank  entered into (i) a Change in Terms
Agreement,  dated as of May 1,  2008,  with  respect  to the $6.5  million  Loan
Facility,  and (ii) a Change in Terms  Agreement,  dated as of May 1, 2008, with
respect to the $10.0 million Loan Facility  (collectively,  the "Change in Terms
Agreements"),  which  agreements  extend the  maturity  date of the $6.5 Million
Facility  and the $10.0  Million  Facility to June 30,  2010 and June 20,  2015,
respectively,  remove the Corporation's  Advanced Digital Imaging Research,  LLC
subsidiary as a guarantor of the indebtedness evidenced thereby,  modify certain
affirmative  and negative  covenants and make such other changes as set forth in
the Change in Terms Agreements,  copies of which are attached hereto as Exhibits
10.1 and 10.2, respectively, and incorporated herein by reference.

Item 9.01. Financial Statements and Exhibits

         (d)      Exhibits.

The following exhibits are filed herewith:

Exhibit
 Number  Description
-------  -----------------------------------------------------------------------
10.1     Change in Terms  Agreement,  dated May 1,  2008,  by and  between  IRIS
         International, Inc. and California Bank & Trust.

10.2     Change in Terms  Agreement,  dated May 1,  2008,  by and  between  IRIS
         International, Inc. and California Bank & Trust.


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                                    SIGNATURE

         Pursuant to the requirements of the Securities Exchange Act of 1934,
the Registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


                                    IRIS INTERNATIONAL, INC.

Date:    June 30, 2008              By: /s/ Peter Donato
                                        ----------------------------------------
                                        Peter Donato
                                        Chief Financial Officer


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                                  EXHIBIT INDEX
Exhibit
 Number  Description
-------  -----------------------------------------------------------------------
10.1     Change in Terms  Agreement,  dated May 1,  2008,  by and  between  IRIS
         International, Inc. and California Bank & Trust.

10.2     Change in Terms  Agreement,  dated May 1,  2008,  by and  between  IRIS
         International, Inc. and California Bank & Trust.


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