Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
MITCHELL DANIEL J
   2. Issuer Name and Ticker or Trading Symbol
REPLIDYNE INC [RDYN] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
SEQUEL VENTURE PARTNERS, L.L.C., 4430 ARAPAHOE AVENUE, SUITE 220		 3. Date of Earliest Transaction (Month/Day/Year)
12/10/2008
(Street)

BOULDER, CO 80303		 4. If Amendment, Date Original Filed(Month/Day/Year)
 6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)		 7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 12/10/2008   P   10,000 A $ 0.7101 69,366 I By The Daniel J. Mitchell Trust
Common Stock 12/10/2008   P   1,760 A $ 0.7 71,126 I By The Daniel J. Mitchell Trust
Common Stock 12/11/2008   P   300 A $ 0.62 71,426 I By The Daniel J. Mitchell Trust
Common Stock 12/11/2008   P   1,700 A $ 0.65 73,126 I By The Daniel J. Mitchell Trust
Common Stock 12/11/2008   P   700 A $ 0.66 73,826 I By The Daniel J. Mitchell Trust
Common Stock 12/11/2008   P   200 A $ 0.665 74,026 I By The Daniel J. Mitchell Trust
Common Stock 12/11/2008   P   3,100 A $ 0.67 77,126 I By The Daniel J. Mitchell Trust
Common Stock 12/11/2008   P   400 A $ 0.675 77,526 I By The Daniel J. Mitchell Trust
Common Stock 12/11/2008   P   1,100 A $ 0.68 78,626 I By The Daniel J. Mitchell Trust
Common Stock               1,412,065 I By Sequel Limited Partnership III (1)
Common Stock               39,240 I By Sequel Entrepreneurs' Fund III, L.P. (1)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)		 6. Date Exercisable and Expiration Date
(Month/Day/Year)		 7. Title and Amount of Underlying Securities
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)		 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)		 11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
MITCHELL DANIEL J
SEQUEL VENTURE PARTNERS, L.L.C.
4430 ARAPAHOE AVENUE, SUITE 220
BOULDER, CO 80303		   X      

Signatures

 /s/ Laura M. Medina, Attorney-in-Fact   12/12/2008
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The Reporting Person is a manager of Sequel Venture Partners III, L.L.C., the general partner of Sequel Limited Partnership III ("SLP III") and Sequel Entrepreneurs' Fund III, L.P. ("SEF III"). As such, the Reporting Person shares voting and investment power over the shares held by SLP III and SEF III and may be deemed to have indirect beneficial ownership of such shares. The Reporting Person disclaims beneficial ownership of such shares held by SLP III and SEF III except to his proportionate pecuniary interest therein.

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