UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940 |
|
| ||||||||||||||||||||||||||||||
|
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. | SEC 1473 (7-02) | ||
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. |
1. Title of Derivative Security (Instr. 4) |
2. Date Exercisable and Expiration Date (Month/Day/Year) |
3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) |
4. Conversion or Exercise Price of Derivative Security | 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5) |
6. Nature of Indirect Beneficial Ownership (Instr. 5) |
||
Date Exercisable | Expiration Date | Title | Amount or Number of Shares |
Reporting Owner Name / Address | Relationships | |||
Director | 10% Owner | Officer | Other | |
First Eagle Value in Biotechnology Master Fund, Ltd. C/O FIRST EAGLE INV. MGMT, GEN. COUNSEL 1345 AVENUE OF THE AMERICAS NEW YORK, NY 10105 |
 |  X |  | See remarks. |
21 APRIL FUND LTD CITCO FUND SERVICES (CAYMAN ISLANDS) LTD REGATTA OFFICE PARK WEST BAY ROAD GRAND CAYMAN, E9 KY1-1205 |
 |  X |  | See remarks. |
21 APRIL FUND LP C/O FIRST EAGLE INV. MGMT., GEN. COUNSEL 1345 AVENUE OF THE AMERICAS, 44TH FLOOR NEW YORK, NY 10105 |
 |  X |  | See remarks. |
DEF Associates N.V. C/O CITCO FUND SERVICES (CURACAO) N.V. KAYA FLAMBOYAN 9, P.O. BOX 812 CURACAO, P8 00000 |
 |  X |  | See remarks. |
Dan DeClue | 06/22/2010 | |
**Signature of Reporting Person | Date | |
Dan DeClue | 06/22/2010 | |
**Signature of Reporting Person | Date | |
Dan DeClue | 06/22/2010 | |
**Signature of Reporting Person | Date | |
Dan DeClue | 06/22/2010 | |
**Signature of Reporting Person | Date |
* | If the form is filed by more than one reporting person, see Instruction 5(b)(v). |
** | Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a). |
(1) | See remarks. |
 Remarks: This amended Form 3 is filed to correct the information filed in the original Form 3 filed on March 5, 2009 (the "Original Form 3"). Except for the updating amendment in this amended Form 3, the Original Form 3 remains in effect. The shares reported on this amended Form 3 consist of 19,452,141 shares held by First Eagle Value in Biotechnology Master Fund, Ltd. ("FEVIBMF"), 2,761,679 shares held by 21 April Fund, L.P. ("21 April LP"), 9,870,442 shares held by 21 April Fund, Ltd. ("21 April Ltd.") and 5,000,000 shares held by DEF Associates N.V. (together with FEVIBMF, 21 April LP and 21 April Ltd., the "Funds"). The Funds may be deemed to be members of a Section 13(d) group owning more than 10% of the issuer's outstanding common stock. Each of the Funds disclaims Section 16 beneficial ownership of the reported securities and this report shall not be deemed an admission that any such Fund is the beneficial owner of such securities, except to the extent of its pecuniary interet therein. |