Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
SAFEGUARD SCIENTIFICS INC
  2. Issuer Name and Ticker or Trading Symbol
CLARIENT, INC [CLRT]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
435 DEVON PARK DRIVE, BUILDING 800
3. Date of Earliest Transaction (Month/Day/Year)
06/19/2006
(Street)

WAYNE, PA 19087-1945
4. If Amendment, Date Original Filed(Month/Day/Year)
06/21/2006
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Units (obligation to buy) (1) (1) 06/19/2006   J(1)   2,352,941     (1)   (1) Common Stock 2,705,882 $ 0 2,352,941 I SSI Delaware (2)
Warrant (right to buy) $ 0.87 06/19/2006   J(3)   50,000   06/19/2006 06/19/2010 Common Stock 50,000 $ 0 50,000 I SSI Delaware (2)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
SAFEGUARD SCIENTIFICS INC
435 DEVON PARK DRIVE
BUILDING 800
WAYNE, PA 19087-1945
    X    

Signatures

 STEVEN J. FEDER   06/21/2006
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) The securities reported herein represent the minimum number of securities which the reporting person has the obligation to purchase from issuer if issuer's acquisition of the assets of Trestle Holdings, Inc. and Trestle Acquisition Corp. (the "Acquisition") is consummated and issuer elects to sell the units to reporting person. Each unit consists of one share of common stock and a warrant to purchase 0.15 shares of common stock. The purchase price for the units will be 85% of the average closing price of issuer's stock for the 10 trading days preceding the issuance (the "Market Price"), not to exceed an effective price of $1.275 per share. The warrant will have an exercise price of 115% of the Market Price and a four-year term. Reporting person's obligation expires upon the earliest of the closing of the Acquisition, termination of the purchase agreement with respect to the Acquisition or 12/31/06.
(2) Safeguard Delaware, Inc. ("SSI Delaware") and Safeguard Scientifics (Delaware), Inc. ("Safeguard Delaware") are wholly-owned subsidiaries of reporting person and the record holders of the securities reported herein.
(3) This warrant was issued to Safeguard Delaware, Inc. in connection with the Issuer's acceptance of a commitment letter from reporting person to provide capital to Issuer.
 
Remarks:
Additional Reporting Persons:

Safeguard Scientifics (Delaware), Inc.
Safeguard Delaware, Inc.
103 Springer Building
3411 Silverside Road
P. O. Box 7048
Wilmington, DE 19803

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