UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                  SCHEDULE 13D
                   Under the Securities Exchange Act of 1934
                                (Amendment No. 4)*


                          AEOLUS PHARMACEUTICALS, INC.
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                                (Name of Issuer)

                    Common Stock, par value $0.01 per share
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                         (Title of Class of Securities)

                                    45325S-10-1
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                                 (CUSIP Number)

                                                    with a copy to:
    Mitchell D. Kaye, Manager                       Steven E. Siesser, Esq.
    Xmark Asset Management, LLC                     Lowenstein Sandler PC
    301 Tresser Boulevard, Suite 1320               65 Livingston Avenue
    Stamford, CT 06901                              Roseland, New Jersey  07068
    (203) 653-2500                                  (973) 597-2506
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                 (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                December 17, 2004
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             (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule l3G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule  because of Sections 240.13d-1(e), 240.13d-1(f)  or 240.13d-1(g), check
the following box. [  ]

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits.  See Section 240.13d-7 for other
parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).




Cusip No.       45325S-10-1
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1.  Names of Reporting Persons.  I.R.S. Identification Nos. of above persons 
    (entities only):
                       Xmark Asset Management, LLC
                               13-3954392
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2.  Check the Appropriate Box if a Member of a Group (See Instructions):
         (a)                  Not 
         (b)               Applicable
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3.  SEC Use Only

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4.  Source of Funds (See Instructions):  WC
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5.  Check if Disclosure  of Legal Proceedings Is Required Pursuant to Items 2(d)
    or 2(e):               Not Applicable
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6.  Citizenship or Place of Organization:    New York, United States

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    Number of                      7. Sole Voting Power:             9,157,687*
                                     -------------------------------------------
    Shares Beneficially            8. Shared Voting Power:                    *
                                     -------------------------------------------
    Owned by
    Each Reporting                 9. Sole Dispositive Power:        8,157,687*
                                      ------------------------------------------
    Person With                    10. Shared Dispositive Power:              *
                                      ------------------------------------------
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11. Aggregate Amount Beneficially Owned by Each Reporting Person:   9,157,687*

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12. Check if  the Aggregate  Amount in  Row (11) Excludes  Certain  Shares  (See
    Instructions):         Not Applicable
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13. Percent of Class Represented by Amount in Row (11):   65.6%*
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14. Type of Reporting Person (See Instructions):  IA
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* On December 17, 2004, Xmark Fund, L.P., a Delaware limited partnership ("Xmark
LP") purchased 28,457 shares of Series B Preferred Stock (the "Series B Shares")
of Aeolus Pharmaceuticals, Inc., a Delaware corporation formerly known as Incara
Pharmaceuticals  Inc. (the  "Company"),  as well as warrants to purchase  22,191
additional Series B Shares.  Xmark LP  simultaneously  converted 28,457 Series B
Shares  into  28,457  shares of common  stock,  par value $0.01 per share of the
Company (the "Common Stock").  The reporting  person is Xmark Asset  Management,
LLC  ("XAM"),  a New York limited  liability  company,  which is the  investment
manager for Xmark LP and the sole manager of Goodnow Capital, L.L.C., a Delaware
limited liability company ("Goodnow"). Goodnow is the holder of 8,107,039 shares
of Common  Stock.  Pursuant to Goodnow's  Operating  Agreement,  management  and
control of Goodnow is vested  exclusively  in the sole manager and, as a result,
XAM  possesses  the  sole  power  to vote  and  direct  the  disposition  of all
securities of the Company owned by Goodnow. Mitchell D. Kaye is Chief Investment
Officer  of XAM,  and as such  possesses  sole  power  to vote  and  direct  the
disposition of all securities of the Company held by Xmark LP and Goodnow.

In addition, pursuant to the terms of a certain Voting Trust Agreement, dated as
of April 19, 2004,  by and among Great Point  Partners,  on behalf of Biomedical
Value Fund,  L.P. and Biomedical  Offshore Value Fund, Ltd.  (collectively,  the
"Biomedical  Funds"), the Company and XAM, as voting trustee: (i) the Biomedical
Funds  transferred into a voting trust (the "Voting Trust") the 1,000,000 shares
of Common Stock (the "Voting Trust Shares")  purchased by the  Biomedical  Funds
from the Company pursuant to that certain Purchase Agreement,  dated as of April
19, 2004 (the "Purchase Agreement"),  by and among the Company and the investors
named  therein,  in exchange  for a voting trust  certificate;  (ii) XAM, as the
voting  trustee of the Voting Trust,  has the exclusive  right and power to vote
the Voting Trust Shares and to give written  consents with respect to any lawful
corporate  action of the  Company;  and (iii) except as set forth in clause (ii)
above, all powers and privileges affecting the Voting Trust Shares attach to the





voting trust certificates  issued in exchange therefor.  While XAM may be deemed
to be the beneficial  owner of the Voting Trust Shares  pursuant to its power to
vote and give written consents with respect to the Voting Trust Shares, XAM does
not own and  expressly  disclaims  any  pecuniary  interest in the Voting  Trust
Shares.

As a result of the fact that XAM possesses the sole power to vote and direct the
disposition  of all shares of Common  Stock of the Company  held by Xmark LP and
Goodnow,  and the sole power to vote the Voting  Trust  Shares,  for purposes of
Reg. Section  240.13d-3,  XAM may be deemed to beneficially own 9,157,687 shares
of Common  Stock,  or 65.6% of the shares deemed  issued and  outstanding  as of
December 17, 2004.







Item 1.   Security and Issuer.
          -------------------

          This statement  relates to the common stock, par value $0.01 per share
(the "Common Stock"), of Aeolus  Pharmaceuticals,  Inc., a Delaware  corporation
formerly known as Incara  Pharmaceuticals Inc. (the "Company").  The Company has
its  principal  executive  offices  at 79 T.W. Alexander  Drive,  4401  Research
Commons, Suite 200, Research Triangle Park, North Carolina 27709.


Item 3.   Source and Amount of Funds or Other Consideration.
          ------------------------------------------------- 

          On December 17, 2004, Xmark Fund, L.P., a Delaware limited partnership
("Xmark LP") purchased  28,457 shares of Series B Preferred Stock (the "Series B
Shares") of the  Company,  as well as warrants  to  purchase  22,191  additional
Series B Shares, for an aggregate  purchase price of $28,457.00.  All funds used
by Xmark LP to purchase the Series B Shares and the warrants  came directly from
the assets of Xmark LP.


Item 4.   Purpose of Transaction.
          ---------------------- 

          Xmark LP and its affiliate, Goodnow, continue to own a majority of the
outstanding  Common Stock. As such, Xmark LP and Goodnow can control the outcome
of matters that may be submitted to the vote of the  Company's  stockholders  at
annual or  special  meetings  of  stockholders.  Xmark LP and  Goodnow  also can
initiate,  through the calling of a special  meeting of  stockholders or through
action by written consent in lieu of a stockholders' meeting,  corporate actions
that are  subject  to the vote of the  Company's  stockholders.  Such  corporate
actions may  include,  and are not limited to, the approval of each of the types
of events described in clauses (a) through (i) under Item 4 of Schedule 13D.


Item 5.   Interest in Securities of the Issuer.
          ------------------------------------ 

          As noted in Item 3 of this Schedule  13D, on December 17, 2004,  Xmark
LP  purchased  28,457  Series B Shares,  as well as warrants to purchase  22,191
additional Series B Shares.  Xmark LP  simultaneously  converted 28,457 Series B
Shares into 28,457 shares of Common  Stock.  XAM is the  investment  manager for
Xmark LP and the sole  manager of  Goodnow.  Goodnow is the holder of  8,107,039
shares of Common Stock.  Pursuant to Goodnow's Operating  Agreement,  management
and  control of Goodnow is vested  exclusively  in the sole  manager  and,  as a
result,  XAM possesses the sole power to vote and direct the  disposition of all
securities of the Company owned by Goodnow. Mitchell D. Kaye is Chief Investment
Officer  of XAM,  and as such  possesses  sole  power  to vote  and  direct  the
disposition of all securities of the Company held by Xmark LP and Goodnow.

          Based upon  information  set forth in the  Company's  annual report on
Form 10-K for the fiscal year ended  September 30, 2004, as of November 30, 2004
there were 13,947,303 shares of Common Stock issued and outstanding. As a result
of the fact that XAM possesses the sole power to vote and direct the disposition
of all shares of Common Stock of the Company  held by Xmark LP and Goodnow,  and
the sole power to vote the Voting Trust  Shares,  for  purposes of Reg.  Section
240.13d-3,  XAM may be deemed to  beneficially  own  9,157,687  shares of Common
Stock,  or 65.6% of the shares deemed issued and  outstanding as of December 17,
2004.







          During the sixty days prior to and  including  December 17, 2004,  the
only transactions in Common Stock, or securities  convertible into,  exercisable
for or exchangeable for Common Stock, by XAM or any person or entity  controlled
by it or any  person  or  entity  for which it  possesses  voting or  investment
control over the securities  thereof,  were the following  transactions,  all of
which took place on December 17, 2004 and all of which were effected in ordinary
brokerage transactions:  (i) the purchase by Xmark LP of 28,457 Series B Shares;
(ii) the purchase by Xmark LP of warrants for additional 22,191 Series B Shares;
and  (iii) the  conversion  by Xmark LP of 28,457  Series B Shares  into  28,457
shares of Common Stock.  Xmark LP purchased the  securities  detailed in (i) and
(ii) of the preceding sentence for an aggregate purchase price of $28,457.00.








                                   Signature
                                   ---------

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


                                      October 3, 2005

                                      XMARK ASSET MANAGEMENT, LLC

                                      /s/ Mitchell D. Kaye
                                      ------------------------------------------
                                      Mitchell D. Kaye, Chief Investment Officer



Attention:  Intentional  misstatements  or omissions of fact constitute  Federal
criminal violations (See 18 U.S.C. 1001).