UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                  SCHEDULE 13D
                   Under the Securities Exchange Act of 1934
                                (Amendment No. 5)*


                          AEOLUS PHARMACEUTICALS, INC.
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                                (Name of Issuer)

                    Common Stock, par value $0.01 per share
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                         (Title of Class of Securities)

                                    45325S-10-1
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                                 (CUSIP Number)

                                                    with a copy to:
    Mitchell D. Kaye, Manager                       Steven E. Siesser, Esq.
    Xmark Asset Management, LLC                     Lowenstein Sandler PC
    301 Tresser Boulevard, Suite 1320               65 Livingston Avenue
    Stamford, CT 06901                              Roseland, New Jersey  07068
    (203) 653-2500                                  (973) 597-2506
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                 (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                  June 30, 2005
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             (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule l3G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule  because of Sections 240.13d-1(e), 240.13d-1(f)  or 240.13d-1(g), check
the following box. [  ]

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits.  See Section 240.13d-7 for other
parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).




Cusip No.       45325S-10-1
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1.  Names of Reporting Persons.  I.R.S. Identification Nos. of above persons 
    (entities only):
                       Xmark Asset Management, LLC
                               13-3954392
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2.  Check the Appropriate Box if a Member of a Group (See Instructions):
         (a)                  Not 
         (b)               Applicable
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3.  SEC Use Only

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4.  Source of Funds (See Instructions):  WC
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5.  Check if Disclosure  of Legal Proceedings Is Required Pursuant to Items 2(d)
    or 2(e):               Not Applicable
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6.  Citizenship or Place of Organization:    New York, United States

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    Number of                      7. Sole Voting Power:             9,322,482*
                                     -------------------------------------------
    Shares Beneficially            8. Shared Voting Power:                    *
                                     -------------------------------------------
    Owned by
    Each Reporting                 9. Sole Dispositive Power:        8,322,482*
                                      ------------------------------------------
    Person With                    10. Shared Dispositive Power:              *
                                      ------------------------------------------
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11. Aggregate Amount Beneficially Owned by Each Reporting Person:   9,322,482*

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12. Check if  the Aggregate  Amount in  Row (11) Excludes  Certain  Shares  (See
    Instructions):         Not Applicable
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13. Percent of Class Represented by Amount in Row (11):   66.6%*
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14. Type of Reporting Person (See Instructions):  IA
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*  On June 30, 2005, Xmark Fund, L.P., a Delaware  limited  partnership  ("Xmark
LP") and Xmark Fund,  Ltd., a Cayman Islands exempted company ("Xmark Ltd") each
purchased  41,150 shares of common stock, par value $0.01 per share (the "Common
Stock") of Aeolus  Pharmaceuticals,  Inc., a Delaware corporation formerly known
as Incara  Pharmaceuticals  Inc. (the "Company").  The reporting person is Xmark
Asset Management,  LLC ("XAM"), a New York limited liability  company,  which is
the  investment  manager  for  Xmark LP and Xmark  Ltd and the sole  manager  of
Goodnow  Capital,  L.L.C.,  a Delaware limited  liability  company  ("Goodnow").
Goodnow is the holder of 8,107,039 shares of Common Stock. Pursuant to Goodnow's
Operating Agreement,  management and control of Goodnow is vested exclusively in
the sole  manager  and, as a result,  XAM  possesses  the sole power to vote and
direct the  disposition  of all  securities  of the  Company  owned by  Goodnow.
Mitchell D. Kaye is Chief Investment  Officer of XAM, and as such possesses sole
power to vote and direct the  disposition  of all securities of the Company held
by Xmark LP, Xmark Ltd and Goodnow.

In addition, pursuant to the terms of a certain Voting Trust Agreement, dated as
of April 19, 2004,  by and among Great Point  Partners,  on behalf of Biomedical
Value Fund,  L.P. and Biomedical  Offshore Value  Fund, Ltd. (collectively,  the
"Biomedical  Funds"), the Company and XAM, as voting trustee: (i) the Biomedical
Funds  transferred into a voting trust (the "Voting Trust") the 1,000,000 shares
of Common Stock (the "Voting Trust Shares")  purchased by the  Biomedical  Funds
from the Company pursuant to that certain Purchase Agreement,  dated as of April
19, 2004 (the "Purchase Agreement"),  by and among the Company and the investors
named  therein,  in exchange  for a voting trust  certificate;  (ii) XAM, as the
voting  trustee of the Voting Trust,  has the exclusive  right and power to vote
the Voting Trust Shares and to give written  consents with respect to any lawful
corporate  action of the  Company;  and (iii) except as set forth in clause (ii)
above, all powers and privileges affecting the Voting Trust Shares attach to the





voting trust certificates  issued in exchange therefor.  While XAM may be deemed
to be the beneficial  owner of the Voting Trust Shares  pursuant to its power to
vote and give written consents with respect to the Voting Trust Shares, XAM does
not own and  expressly  disclaims  any  pecuniary  interest in the Voting  Trust
Shares.

As a result of the fact that XAM possesses the sole power to vote and direct the
disposition of all shares of Common Stock of the Company held by Xmark LP, Xmark
Ltd and  Goodnow,  and the sole  power  to vote the  Voting  Trust  Shares,  for
purposes  of Reg.  Section  240.13d-3,  XAM may be  deemed to  beneficially  own
9,322,482  shares of Common  Stock,  or 66.6% of the  shares  deemed  issued and
outstanding as of June 30, 2005.






Item 3.   Source and Amount of Funds or Other Consideration.
          ------------------------------------------------- 

          On June 30, 2005,  Xmark Fund,  L.P., a Delaware  limited  partnership
("Xmark LP") and Xmark Fund,  Ltd., a Cayman Islands  exempted  company  ("Xmark
Ltd") each  purchased  41,150  shares of Common Stock of the Company.  All funds
used by Xmark LP and Xmark Ltd to  purchase  the  shares  of Common  Stock  came
directly from the assets of Xmark LP and Xmark Ltd, respectively.


Item 5.   Interest in Securities of the Issuer.
          ------------------------------------ 

          Based upon information set forth in the Company's  quarterly report on
Form 10-Q for the  quarter  ended March 31,  2005,  as of May 3, 2005 there were
13,975,760  shares of Common  Stock issued and  outstanding.  As a result of the
fact that XAM possesses the sole power to vote and direct the disposition of all
shares of Common  Stock of the Company  held by Xmark LP, Xmark Ltd and Goodnow,
and the sole power to vote the Voting Trust Shares, for purposes of Reg. Section
240.13d-3,  XAM may be deemed to  beneficially  own  9,322,482  shares of Common
Stock, or 66.6% of the shares deemed issued and outstanding as of June 30, 2005.

          During the sixty days prior to and including  June 30, 2005,  the only
transactions in Common Stock, or securities convertible into, exercisable for or
exchangeable  for Common Stock, by XAM or any person or entity  controlled by it
or any person or entity for which it possesses voting or investment control over
the  securities  thereof,  were the  following  transactions,  all of which were
effected in ordinary brokerage transactions:


                                   I. Xmark LP
                                   -----------

                                   (Purchases)

        Date                          Amount                   Price
        ----                          ------                   -----
      06/30/05                         6,150                   $0.67
      06/30/05                        35,000                   $0.88


                                  II. Xmark Ltd
                                  -------------

                                   (Purchases)

        Date                          Amount                   Price
        ----                          ------                   -----
      06/30/05                         6,150                   $0.67
      06/30/05                        35,000                   $0.88







                                   Signature
                                   ---------

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


                                      October 3, 2005

                                      XMARK ASSET MANAGEMENT, LLC

                                      /s/ Mitchell D. Kaye
                                      ------------------------------------------
                                      Mitchell D. Kaye, Chief Investment Officer



Attention:  Intentional  misstatements  or omissions of fact constitute  Federal
criminal violations (See 18 U.S.C. 1001).