UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                  SCHEDULE 13D
                   Under the Securities Exchange Act of 1934
                                (Amendment No. 6)*


                          AEOLUS PHARMACEUTICALS, INC.
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                                (Name of Issuer)

                    Common Stock, par value $0.01 per share
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    45325S-10-1
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                                 (CUSIP Number)

                                                    with a copy to:
    Mitchell D. Kaye, Manager                       Peter D. Greene, Esq.
    Xmark Asset Management, LLC                     Lowenstein Sandler PC
    301 Tresser Boulevard, Suite 1320               1251 Avenue of the Americas
    Stamford, CT 06901                              New York, NY 10020
    (203) 653-2500                                  (973) 262-6700
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                 (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                November 21, 2005
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             (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule l3G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule  because of Sections 240.13d-1(e), 240.13d-1(f)  or 240.13d-1(g), check
the following box. [  ]

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits.  See Section 240.13d-7 for other
parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).




Cusip No.       45325S-10-1
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1.  Names of Reporting Persons.  I.R.S. Identification Nos. of above persons 
    (entities only):
                       Xmark Asset Management, LLC
                               13-3954392
--------------------------------------------------------------------------------
2.  Check the Appropriate Box if a Member of a Group (See Instructions):
         (a)               
         (b)    X          
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3.  SEC Use Only

--------------------------------------------------------------------------------
4.  Source of Funds (See Instructions):  WC
--------------------------------------------------------------------------------
5.  Check if Disclosure  of Legal Proceedings Is Required Pursuant to Items 2(d)
    or 2(e):               Not Applicable
--------------------------------------------------------------------------------
6.  Citizenship or Place of Organization:    New York, United States

--------------------------------------------------------------------------------
    Number of                      7. Sole Voting Power:              9,387,502*
                                     -------------------------------------------
    Shares Beneficially            8. Shared Voting Power:                    *
                                     -------------------------------------------
    Owned by
    Each Reporting                 9. Sole Dispositive Power:         8,387,502*
                                      ------------------------------------------
    Person With                    10. Shared Dispositive Power:              *
                                      ------------------------------------------
--------------------------------------------------------------------------------
11. Aggregate Amount Beneficially Owned by Each Reporting Person:   9,387,502*

--------------------------------------------------------------------------------
12. Check if  the Aggregate  Amount in  Row (11) Excludes  Certain  Shares  (See
    Instructions):         Not Applicable
--------------------------------------------------------------------------------
13. Percent of Class Represented by Amount in Row (11):   66.6%*
--------------------------------------------------------------------------------
14. Type of Reporting Person (See Instructions):  IA
--------------------------------------------------------------------------------

* This is a joint  filing by Xmark  Asset  Management,  LLC, a New York  limited
liability  company  ("XAM"),  and Xmark  Opportunity  Partners,  LLC, a Delaware
limited  liability  company  ("Opportunity  Partners"  and together with XAM the
"Reporting  Persons").  Mitchell D. Kaye,  the Chief  Executive  Officer of XAM,
exercises  sole  voting  and  investment  power with  respect to all  securities
beneficially  owned by XAM,  and Mr.  Kaye  and  David C.  Cavalier,  the  Chief
Executive  Officer and Chief  Operating  Officer,  respectively,  of Opportunity
Partners,  share  voting and  investment  power with  respect to all  securities
beneficially owned by Opportunity Partners.

As of November  21,  2005,  Xmark Fund,  L.P.,  a Delaware  limited  partnership
("Xmark LP"),  held 143,354  shares of common  stock,  par value $0.01 per share
("Common  Stock"),  of Aeolus  Pharmaceuticals,  Inc.,  a Delaware  corporation,
formerly known as Incara  Pharmaceuticals  Corporation  (the  "Company").  As of
November 21,  2005,  Xmark LP also held a warrant to purchase  22,191  shares of
Series B  Preferred  Stock of the  Company,  which was  convertible  into 22,191
shares of Common  Stock of the  Company.  This  warrant  expired on December 21,
2005.  As of November 21, 2005,  Xmark Fund,  Ltd.,  a Cayman  Islands  exempted
company ("Xmark Ltd"),  held 114,898 shares of Common Stock of the Company.  XAM
is the investment manager of Xmark LP and Xmark Ltd and, as such, possesses sole
power to vote and direct the  disposition  of all securities of the Company held
by Xmark LP and Xmark Ltd.

As of November 21, 2005,  Goodnow Capital,  L.L.C., a Delaware limited liability
company  ("Goodnow"),  held 8,107,059 shares of Common Stock of the Company. XAM
is the sole  manager of Goodnow and, as such,  possesses  sole power to vote and
direct the disposition of all securities of the Company held by Goodnow.

As of November  21,  2005,  Biomedical  Value  Fund,  L.P.,  a Delaware  limited
partnership, and Biomedical Offshore Value Fund, Ltd., a Cayman Islands exempted
company (together the "Biomedical Value Funds"), held 1,000,000 shares of Common
Stock of the  Company  (the  "Biomedical  Shares")  that are subject to a Voting
Trust  Agreement,  dated April 19, 2004, by and among (i) the  Biomedical  Value
Funds, (ii) XAM, and (iii) the Company.  Pursuant to the Voting Trust Agreement,
XAM is the  Voting  Trustee  and,  as  such,  possesses  sole  power to vote the
Biomedical  Shares.  While XAM may be deemed to be the  beneficial  owner of the
Biomedical Shares pursuant to its power to vote the Biomedical  Shares, XAM does
not own, and  expressly  disclaims  any  pecuniary  interest in, the  Biomedical
Shares.  XAM does not  exercise  any  investment  authority  with respect to the
Biomedical  Shares. The Biomedical Value Funds, in their capacity as the holders
of voting and/or investment authority of more than 5% of the Common Stock of the
Company,  separately  and/or in the aggregate,  pursuant to Reg. 13d-3 (jointly,
together with certain other reporting  persons) file statements  separately from
the Reporting  Persons pursuant to Section 13 of the Securities  Exchange Act of
1934, as amended.

As a result of the foregoing,  for purposes of Reg.  Section  240.13d-3,  XAM is
deemed to beneficially own 9,387,502  shares of Common Stock of the Company,  or
66.6% of the shares of Common Stock of the Company deemed issued and outstanding
as of November 21, 2005.


Cusip No.        45325S-10-1                                                    
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1.  Names of Reporting Persons.  I.R.S. Identification Nos. of above persons 
    (entities only):
                      Xmark Opportunity Partners, LLC
                              20-2052197
--------------------------------------------------------------------------------
2.  Check the Appropriate Box if a Member of a Group (See Instructions):
         (a)                  
         (b)   X            
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3.  SEC Use Only

--------------------------------------------------------------------------------
4.  Source of Funds (See Instructions):  WC
--------------------------------------------------------------------------------
5.  Check if Disclosure  of Legal Proceedings Is Required Pursuant to Items 2(d)
    or 2(e):               Not Applicable
--------------------------------------------------------------------------------
6.  Citizenship or Place of Organization:   Delaware, United States

--------------------------------------------------------------------------------
    Number of                      7. Sole Voting Power:              4,300,000*
                                     -------------------------------------------
    Shares Beneficially            8. Shared Voting Power:                    *
                                     -------------------------------------------
    Owned by
    Each Reporting                 9. Sole Dispositive Power:         4,300,000*
                                      ------------------------------------------
    Person With                    10. Shared Dispositive Power:              *
                                      ------------------------------------------
--------------------------------------------------------------------------------
11. Aggregate Amount Beneficially Owned by Each Reporting Person:   4,300,000*

--------------------------------------------------------------------------------
12. Check if  the Aggregate  Amount in  Row (11) Excludes  Certain  Shares  (See
    Instructions):         Not Applicable
--------------------------------------------------------------------------------
13. Percent of Class Represented by Amount in Row (11):   23.4%*
--------------------------------------------------------------------------------
14. Type of Reporting Person (See Instructions):  IA
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* This is a joint  filing by Xmark  Asset  Management,  LLC, a New York  limited
liability  company  ("XAM"),  and Xmark  Opportunity  Partners,  LLC, a Delaware
limited  liability  company  ("Opportunity  Partners"  and together with XAM the
"Reporting  Persons").  Mitchell D. Kaye,  the Chief  Executive  Officer of XAM,
exercises  sole  voting  and  investment  power with  respect to all  securities
beneficially  owned by XAM,  and Mr.  Kaye  and  David C.  Cavalier,  the  Chief
Executive  Officer and Chief  Operating  Officer,  respectively,  of Opportunity
Partners,  share  voting and  investment  power with  respect to all  securities
beneficially owned by Opportunity Partners.

As of November 21,  2005,  Xmark  Opportunity  Fund,  L.P.,  a Delaware  limited
partnership  ("Opportunity  LP"),  held 330,000  shares of Series A  Convertible
Preferred  Stock,  par value $0.01 per share  ("Series A Preferred  Stock"),  of
Aeolus Pharmaceuticals,  Inc., a Delaware corporation,  formerly known as Incara
Pharmaceuticals  Corporation (the  "Company").  Each share of Series A Preferred
Stock of the Company is convertible  into two shares of common stock,  par value
$0.01 per share ("Common Stock"),  of the Company at a conversion price of $1.00
per share.  As of November  21, 2005,  Xmark  Opportunity  Fund,  Ltd., a Cayman
Islands exempted company  ("Opportunity  Ltd"),  held 495,000 shares of Series A
Preferred  Stock of the Company,  which are  convertible  into 990,000 shares of
Common  Stock of the  Company.  As of November  21,  2005,  Xmark JV  Investment
Partners,  LLC, a Delaware  limited  liability  company  ("JV  Partners"),  held
250,000 shares of Series A Preferred Stock of the Company, which are convertible
into 500,000  shares of Common  Stock of the  Company.  As of November 21, 2005,
Opportunity  LP held warrants to purchase  660,000 shares of Common Stock of the
Company  at an  exercise  price of $1.00 per share.  As of  November  21,  2005,
Opportunity Ltd held warrants to purchase  990,000 shares of Common Stock of the
Company at an exercise  price of $1.00 per share.  As of November 21,  2005,  JV
Partners held warrants to purchase 500,000 shares of Common Stock of the Company
at an exercise price of $1.00 per share. All of the warrants held by Opportunity
LP,  Opportunity Ltd and JV Partners are exercisable  within 60 days of the date
of  event  which  required  filing  of this  Amendment  No. 6 to  Schedule  13D.
Opportunity Partners is the sole member of the investment manager of Opportunity
LP and Opportunity Ltd and, as such, possesses sole power to vote and direct the
disposition  of all  securities  of  the  Company  held  by  Opportunity  LP and
Opportunity Ltd.  Opportunity  Partners is the investment manager of JV Partners
and, as such,  possesses  sole power to vote and direct the  disposition  of all
securities of the Company held by JV Partners.

As  a  result  of  the  foregoing,  for  purposes  of  Reg.  Section  240.13d-3,
Opportunity  Partners is deemed to beneficially  own 4,300,000  shares of Common
Stock of the  Company,  or 23.4% of the  shares of Common  Stock of the  Company
deemed issued and outstanding as of November 21, 2005.





THIS  AMENDMENT  NO. 6 TO  SCHEDULE  13D IS BEING  FILED  JOINTLY BY XMARK ASSET
MANAGEMENT,  LLC,  A NEW YORK  LIMITED  LIABILITY  COMPANY  ("XAM"),  AND  XMARK
OPPORTUNITY  PARTNERS,  LLC, A DELAWARE LIMITED LIABILITY COMPANY  ("OPPORTUNITY
PARTNERS"  AND  TOGETHER  WITH XAM THE  "REPORTING  PERSONS"),  PURSUANT TO RULE
13d-1(k) OF THE  SECURITIES  EXCHANGE  ACT OF 1934,  AS AMENDED  (THE  "EXCHANGE
ACT").  THIS  STATEMENT  CONSTITUTES  AMENDMENT NO. 6 TO THE SCHEDULE 13D OF XAM
FILED ON DECEMBER 1, 2003.  THIS  STATEMENT  CONSTITUTES  THE INITIAL  FILING ON
SCHEDULE 13D OF OPPORTUNITY  PARTNERS.  NEITHER THE FILING OF THIS SCHEDULE 13D,
AS AMENDED,  NOR ANY OF ITS CONTENTS  SHALL BE DEEMED TO CONSTITUTE AN ADMISSION
BY THE REPORTING  PERSONS OR ANY OTHER PERSON THAT IT IS THE BENEFICIAL OWNER OF
THE SECURITIES OF THE COMPANY  BENEFICIALLY OWNED BY ANY OTHER PERSON (INCLUDING
THE OTHER REPORTING PERSON) FOR PURPOSES OF SECTION 13(d) OF THE EXCHANGE ACT OR
FOR ANY OTHER PURPOSE, AND SUCH BENEFICIAL OWNERSHIP IS EXPRESSLY DISCLAIMED.

Item 1.   Securities of Issuer.
          --------------------

          Item 1 of the Schedule 13D is hereby further  amended by deleting such
item in its entirety and substituting the following in lieu thereof:

          This statement  relates to the shares of common stock, par value $0.01
per  share  ("Common  Stock"),  of  Aeolus  Pharmaceuticals,  Inc.,  a  Delaware
corporation,   formerly  known  as  Incara   Pharmaceuticals   Corporation  (the
"Company").  The  Company  has  principal  executive  offices  located  at 23811
Inverness Place, Laguna Niguel, California 92677.

Item 2.   Identity and Background.
          -----------------------

          Item 2 of the Schedule 13D is hereby further  amended by deleting such
item in its entirety and substituting the following in lieu thereof:

          XAM is a New  York  limited  liability  company.  The  address  of the
principal  office  of  XAM is  301  Tresser  Boulevard,  Suite  1320,  Stamford,
Connecticut  06901. XAM serves as the investment  manager of Xmark Fund, L.P., a
Delaware  limited  partnership  ("Xmark  LP"),  and Xmark Fund,  Ltd.,  a Cayman
Islands  exempted company ("Xmark Ltd"),  and, as such,  possesses sole power to
vote and direct the  disposition  of all securities of the Company held by Xmark
LP and Xmark  Ltd.  XAM also  serves as the sole  manager  of  Goodnow  Capital,
L.L.C.,  a Delaware  limited  liability  company  ("Goodnow").  Pursuant  to the
Operating  Agreement  of  Goodnow,  management  and control of Goodnow is vested
exclusively  in the sole manager and, as a result,  XAM possesses the sole power
to vote and direct the  disposition  of all  securities  of the Company  held by
Goodnow. Mitchell D. Kaye, whose business address is c/o Xmark Asset Management,
LLC, 301 Tresser  Boulevard,  Suite 1320,  Stamford,  Connecticut  06901, is the
Chief Executive Officer and the managing member of XAM. XAM, through one or more
funds and/or  accounts  managed by it and/or its  affiliates,  is engaged in the
investment in personal  property of all kinds,  including,  without  limitation,
subscriptions,  warrants, bonds, notes, debentures, options and other securities
of whatever  kind and nature.  Mr.  Kaye,  directly or  indirectly,  through XAM
and/or one or more funds and/or  accounts  managed by it and/or its  affiliates,
also provides  investment  management  and other services to various other third
parties.

          Opportunity  Partners is a Delaware  limited  liability  company.  The
address  of  the  principal  office  of  Opportunity  Partners  is  301  Tresser
Boulevard, Suite 1320, Stamford,  Connecticut 06901. Opportunity Partners is (i)
the sole member of the investment  manager of Xmark  Opportunity  Fund,  L.P., a
Delaware limited  partnership  ("Opportunity  LP"), and Xmark  Opportunity Fund,
Ltd.,  a Cayman  Islands  exempted  company  ("Opportunity  Ltd"),  and (ii) the
investment  manager of Xmark JV  Investment  Partners,  LLC, a Delaware  limited
liability  company ("JV Partners"),  and, as such,  possesses sole power to vote
and direct the  disposition of all securities of the Company held by Opportunity
LP, Opportunity Ltd and JV Partners.  David C. Cavalier,  whose business address
is c/o Xmark  Opportunity  Partners,  LLC,  301 Tresser  Boulevard,  Suite 1320,
Stamford,  Connecticut  06901,  and  Mitchell  D. Kaye are the  Chief  Operating
Officer and Chief  Executive  Officer,  respectively,  of Opportunity  Partners.
Opportunity  Partners,  through one or more funds and/or accounts  managed by it
and/or its affiliates,  is engaged in the investment in personal property of all
kinds, including,  without limitation,  subscriptions,  warrants,  bonds, notes,
debentures,  options  and other  securities  of whatever  kind and  nature.  Mr.
Cavalier,  directly or indirectly,  through  Opportunity  Partners and/or one or
more funds and/or accounts  managed by it and/or its  affiliates,  also provides
investment management and other services to various other third parties.

          The sole  managing  member of  Opportunity  Partners is Xmark  Capital
Partners,  LLC,  a Delaware  limited  liability  company,  which  maintains  its
principal office at 301 Tresser  Boulevard,  Suite 1320,  Stamford,  Connecticut
06901.  The sole  members of Xmark  Capital  Partners,  LLC are Mr. Kaye and Mr.
Cavalier.  Messrs.  Kaye and  Cavalier  share voting and  investment  power with
respect to all securities beneficially owned by Opportunity Partners.

          None of the Reporting Persons (nor to the Reporting Persons' knowledge
any other  person  named in this Item 2) have been,  during the past five years,
(i) convicted in a criminal proceeding (excluding traffic violations and similar
misdemeanors)  or  (ii)  a  party  to  a  civil  proceeding  of  a  judicial  or
administrative  body of  competent  jurisdiction  which had the result of any of
them  being  subject  to a  judgment,  decree or final  order  enjoining  future
violations  of, or prohibiting  or mandating  activities  subject to, federal or
state securities laws or finding any violation with respect to such laws.

          Each of  Mitchell  D. Kaye and David C.  Cavalier  is a citizen of the
United States.

Item 3.   Source and Amount of Funds or Other Consideration.
          -------------------------------------------------

          Item 3 of the  Schedule  13D is hereby  further  amended by adding the
following at the end thereof:

          On November 21, 2005,  pursuant to a Purchase Agreement dated November
21, 2005, between the Company and certain investors listed therein,  Opportunity
LP purchased  330,000 shares of Series A Convertible  Preferred Stock, par value
$0.01 per share  ("Series A Preferred  Stock"),  of the  Company,  at a price of
$2.00 per share, for an aggregate  purchase price of $660,000,  and was issued a
warrant to purchase 660,000 shares of Common Stock of the Company at an exercise
price of $1.00 per share.  Each share of Series A Preferred Stock of the Company
is  convertible  into two shares of Common  Stock of the Company at a conversion
price of $1.00 per share. On November 21, 2005, pursuant to a Purchase Agreement
dated  November  21,  2005,  between the Company  and certain  investors  listed
therein, Opportunity Ltd purchased 495,000 shares of Series A Preferred Stock of
the Company,  at a price of $2.00 per share, for an aggregate  purchase price of
$990,000, and was issued a warrant to purchase 990,000 shares of Common Stock of
the  Company at an exercise  price of $1.00 per share.  On  November  21,  2005,
pursuant to a Purchase  Agreement  dated November 21, 2005,  between the Company
and certain  investors listed therein,  JV Partners  purchased 250,000 shares of
Series A  Preferred  Stock,  at a price of $2.00  per  share,  for an  aggregate
purchase price of $500,000,  and was issued a warrant to purchase 500,000 shares
of Common  Stock of the  Company at an  exercise  price of $1.00 per share.  All
funds used to purchase the  securities of the Company set forth herein on behalf
of Opportunity LP, Opportunity Ltd and JV Partners came directly from the assets
of Opportunity LP, Opportunity Ltd and JV Partners, respectively.

Item 4.   Purpose of Transaction.
          ----------------------

          Item 4 of the Schedule 13D is hereby further  amended by deleting such
item in its entirety and substituting the following in lieu thereof:

          Each of the  Reporting  Persons  intends to  separately  evaluate  the
performance of the shares of Common Stock of the Company as an investment.  Each
of the  Reporting  Persons  pursues an investment  objective  that seeks capital
appreciation.  In pursuing this  investment  objective,  each  Reporting  Person
separately  analyzes the operations,  capital structure and markets of companies
in which such Reporting  Person's  clients invest,  including the Company,  on a
continuous  basis through,  among other things,  analysis of  documentation  and
discussions   with   knowledgeable   industry  and  market  observers  and  with
representatives of such companies.

          Each  Reporting  Person intends to  continuously  assess the Company's
business,  financial  condition,  results of operations and  prospects,  general
economic conditions,  the securities markets in general and those for the shares
of Common  Stock of the  Company in  particular,  other  developments  and other
investment opportunities.  Depending on such assessments,  each Reporting Person
may acquire  additional  securities  of the Company or may  determine to sell or
otherwise dispose of all or some of the securities of the Company presently held
by Xmark LP,  Xmark Ltd,  Goodnow,  Opportunity  LP,  Opportunity  Ltd and/or JV
Partners,  as applicable,  in the open market or in private  transactions.  Such
actions will depend upon a variety of factors,  including,  without  limitation,
current and anticipated  future trading prices for the shares of Common Stock of
the Company, the financial condition, results of operations and prospects of the
Company,  alternative  investment  opportunities,  general  economic,  financial
market and industry  conditions and other factors that each Reporting Person may
deem material to its investment decision.

          David  C.  Cavalier,   the  Chief  Operating  Officer  of  Opportunity
Partners,  is currently a director and Chairman of the Board of the Company.  In
addition, XAM alone, and the Reporting Persons in the aggregate,  through one or
more  intermediate  entities,  possess(es)  the  power  to vote and  direct  the
disposition  of more than a majority of the  outstanding  shares (and the shares
deemed  outstanding for purposes of Reg.  Section  240.13d-3) of Common Stock of
the  Company.  As such,  one or more of the  Reporting  Persons  can control the
outcome  of  matters  that  may be  submitted  to  the  vote  of  the  Company's
stockholders at annual or special meetings of  stockholders.  One or more of the
Reporting Persons also can initiate, through the calling of a special meeting of
stockholders  or through  action by written  consent in lieu of a  stockholders'
meeting,  corporate  actions  that  are  subject  to the  vote of the  Company's
stockholders.  Such  corporate  actions may  include,  without  limitation,  the
approval  of each of the types of events  described  in clauses  (a) through (j)
under  Item 4 of  Schedule  13D.  Except  as  otherwise  described  herein,  the
Reporting  Persons,  separately or together,  do not presently have any plans or
proposals  which relate to or would  result in the types of events  described in
clauses (a) through (j) under Item 4 of Schedule 13D.

Item 5.   Interest in Securities of the Issuer.
          ------------------------------------

          Item 5 of the Schedule 13D is hereby further  amended by deleting such
item in its entirety and substituting the following in lieu thereof:

          As of November 21, 2005,  Xmark LP held 143,354 shares of Common Stock
of the  Company.  As of  November  21,  2005,  Xmark LP also held a  warrant  to
purchase  22,191  shares of Series B Preferred  Stock of the Company,  which was
convertible  into 22,191  shares of Common  Stock of the  Company.  This warrant
expired on December  21, 2005.  As of November 21, 2005,  Xmark Ltd held 114,898
shares of Common Stock of the Company. XAM is the investment manager of Xmark LP
and  Xmark  Ltd and,  as such,  possesses  sole  power  to vote and  direct  the
disposition of all securities of the Company held by Xmark LP and Xmark Ltd.

          As of November 21, 2005, Goodnow held 8,107,059 shares of Common Stock
of the Company.  XAM is the sole manager of Goodnow and, as such, possesses sole
power to vote and direct the  disposition  of all securities of the Company held
by Goodnow.

          As of November  21,  2005,  Biomedical  Value Fund,  L.P.,  a Delaware
limited partnership,  and Biomedical Offshore Value Fund, Ltd., a Cayman Islands
exempted company (together the "Biomedical Value Funds"),  held 1,000,000 shares
of Common Stock of the Company (the  "Biomedical  Shares") that are subject to a
Voting Trust  Agreement,  dated April 19, 2004, by and among (i) the  Biomedical
Value  Funds,  (ii) XAM,  and (iii) the  Company.  Pursuant to the Voting  Trust
Agreement,  XAM is the Voting Trustee and, as such, possesses sole power to vote
the Biomedical Shares. While XAM may be deemed to be the beneficial owner of the
Biomedical Shares pursuant to its power to vote the Biomedical  Shares, XAM does
not own, and  expressly  disclaims  any  pecuniary  interest in, the  Biomedical
Shares.  XAM does not  exercise  any  investment  authority  with respect to the
Biomedical  Shares. The Biomedical Value Funds, in their capacity as the holders
of voting and/or investment authority of more than 5% of the Common Stock of the
Company,  separately  and/or in the aggregate,  pursuant to Reg. 13d-3 (jointly,
together with certain other reporting  persons) file statements  separately from
the Reporting Persons pursuant to Section 13 of the Exchange Act.

          As of November 21, 2005,  Opportunity LP held 330,000 shares of Series
A Preferred Stock of the Company.  Each share of Series A Preferred Stock of the
Company  is  convertible  into two  shares of Common  Stock of the  Company at a
conversion  price of $1.00 per share.  As of November 21, 2005,  Opportunity Ltd
held  495,000  shares  of Series A  Preferred  Stock of the  Company,  which are
convertible  into 990,000 shares of Common Stock of the Company.  As of November
21, 2005,  JV Partners  held 250,000  shares of Series A Preferred  Stock of the
Company,  which are  convertible  into  500,000  shares  of Common  Stock of the
Company.  As of November  21,  2005,  Opportunity  LP held  warrants to purchase
660,000  shares of Common Stock of the Company at an exercise price of $1.00 per
share.  As of  November  21,  2005,  Opportunity  Ltd held  warrants to purchase
990,000  shares of Common Stock of the Company at an exercise price of $1.00 per
share.  As of November 21, 2005, JV Partners  held warrants to purchase  500,000
shares of Common  Stock of the Company at an exercise  price of $1.00 per share.
All of the warrants held by Opportunity LP,  Opportunity Ltd and JV Partners are
exercisable  within 60 days of the date of event which  required  filing of this
Amendment No. 6 to Schedule 13D.  Opportunity Partners is the sole member of the
investment manager of Opportunity LP and Opportunity Ltd and, as such, possesses
sole power to vote and direct the  disposition  of all securities of the Company
held  by  Opportunity  LP  and  Opportunity  Ltd.  Opportunity  Partners  is the
investment manager of JV Partners and, as such, possesses sole power to vote and
direct the disposition of all securities of the Company held by JV Partners.

          Based upon information  received from the Company,  as of November 21,
2005, there were 14,083,259 shares of Common Stock issued and outstanding.  As a
result of the foregoing,  for purposes of Reg. Section 240.13d-3,  XAM is deemed
to beneficially own 9,387,502 shares of Common Stock of the Company, or 66.6% of
the shares of Common Stock of the Company  deemed issued and  outstanding  as of
November  21,  2005,  and  Opportunity  Partners is deemed to  beneficially  own
4,300,000  shares  of Common  Stock of the  Company,  or 23.4% of the  shares of
Common Stock of the Company  deemed  issued and  outstanding  as of November 21,
2005.

          Except as  described in Item 3 of this  statement on Schedule  13D, as
amended, during the 60 days prior to and including November 21, 2005, there were
no purchases or sales of Common Stock of the Company, or securities  convertible
into,  exercisable for or exchangeable  for Common Stock of the Company,  by the
Reporting  Persons,  or any person or entity controlled by the Reporting Persons
or any  person or  entity  for which the  Reporting  Persons  possess  voting or
investment control over the securities thereof. In addition, except as described
in this Schedule 13D, as amended,  to the knowledge of the Reporting Persons, no
other  securities of the Company are owned,  beneficially  or otherwise,  by any
other person named in Item 2 above. Except as described in this Schedule 13D, as
amended,  to the  knowledge of the Reporting  Persons,  no other person named in
Item 2 has effected any  transactions  in shares of Common Stock of the Company,
or securities convertible into, exercisable for or exchangeable for Common Stock
of the Company, during the 60 days on or prior to November 21, 2005.

          Neither the filing of this  Schedule  13D, as amended,  nor any of its
contents shall be deemed to constitute an admission by the Reporting  Persons or
any  other  person  that it is the  beneficial  owner of the  securities  of the
Company  beneficially  owned by any other person  (including the other Reporting
Person)  for  purposes  of Section  13(d) of the  Exchange  Act or for any other
purpose, and such beneficial ownership is expressly disclaimed.

Item 7.   Material to be Filed as Exhibits.
          --------------------------------

          Item 7 of the  Schedule  13D is hereby  further  amended by adding the
following at the end thereof:

          A. Joint filing agreement, dated as of January 29, 2006 by and between
Xmark Asset Management, LLC and Xmark Opportunity Partners, LLC.



                                   Signature
                                   ---------

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


January 30, 2006                      XMARK ASSET MANAGEMENT, LLC

                                      /s/ Mitchell D. Kaye
                                      ------------------------------------------
                                      Name:  Mitchell D. Kaye
                                      Title: Chief Executive Officer


January 30, 2006                      XMARK OPPORTUNITY PARTNERS, LLC

                                      /s/ Mitchell D. Kaye
                                      ------------------------------------------
                                      Name:  Mitchell D. Kaye
                                      Title: Chief Executive Officer



Attention:  Intentional  misstatements  or omissions of fact constitute  Federal
criminal violations (See 18 U.S.C. 1001).



                                    Exhibit A

                             JOINT FILING AGREEMENT

          The undersigned  agree that this Schedule 13D Amendment No. 6 relating
to the shares of common stock of Aeolus  Pharmaceuticals,  Inc. is filed jointly
on behalf of each of the undersigned pursuant to Rule 13d-1(k).

Dated:  January 29, 2006

                                      XMARK ASSET MANAGEMENT, LLC


                                      By:/s/ Mitchell D. Kaye 
                                         -------------------------
                                         Name:  Mitchell D. Kaye
                                         Title: Chief Executive Officer


                                      XMARK OPPORTUNITY PARTNERS, LLC


                                      By:/s/ Mitchell D. Kaye       
                                         -------------------------
                                         Name:  Mitchell D. Kaye
                                         Title: Chief Executive Officer