UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934

                               (Amendment No. 2)*



                         AVANT IMMUNOTHERAPEUTICS, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)

                    Common Stock, par value $0.001 per share
--------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                    053491106
--------------------------------------------------------------------------------
                                 (CUSIP Number)

                                December 31, 2007
--------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to  which this Schedule
13G is filed:

         [ ] Rule 13d-1(b)
         [X] Rule 13d-1(c)
         [ ] Rule 13d-1(d)



*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).





CUSIP No.  053491106
--------------------------------------------------------------------------------

(1)  Names of Reporting Persons.   I.R.S.  Identification  Nos. of Above Persons
     (entities only):

      Thomas S. Paluck
--------------------------------------------------------------------------------

(2)  Check the Appropriate Box if a Member of a Group (See Instructions)
        (a) [ ]
        (b) [X]
--------------------------------------------------------------------------------

(3)     SEC Use Only
--------------------------------------------------------------------------------

(4)     Citizenship or Place of Organization:  United States
--------------------------------------------------------------------------------
Number of Shares Beneficially Owned
  by Each Reporting Person            (5) Sole Voting Power:                  0*
                                          --------------------------------------
                                      (6) Shared Voting Power:        1,000,000*
                                          --------------------------------------
                                      (7) Sole Dispositive Power:     6,632,346*
                                          --------------------------------------
                                      (8) Shared Dispositive Power:   1,000,000*
                                          --------------------------------------
--------------------------------------------------------------------------------
 (9) Aggregate Amount Beneficially Owned by Each Reporting Person:

             7,632,346*
--------------------------------------------------------------------------------

(10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See
     Instructions):   [ ]
--------------------------------------------------------------------------------

(11) Percent of Class Represented by Amount in Row (9):  10.3%*
--------------------------------------------------------------------------------

(12) Type of Reporting Person (See Instructions):  IN
--------------------------------------------------------------------------------
* Based on information  set forth on the Form 10-Q of AVANT  Immunotherapeutics,
Inc. (the  "Company") as filed with the  Securities  and Exchange  Commission on
November 7, 2007, there were 74,188,066 shares of common stock, par value $0.001
per share (the  "Shares"),  of the Company issued and outstanding as of November
5, 2007. As of December 31, 2007 (the  "Reporting  Date"),  Thomas S. Paluck and
Dorothy Paluck held 770,000 and 230,000 Shares, respectively. In addition, as of
the Reporting  Date, TSP Capital  Management  Group,  LLC ("TSP") managed one or
more private  investment  accounts on behalf of various  clients  (the  "Managed
Accounts"),  which owned in the aggregate  6,632,346  Shares.  Mr. Paluck is the
sole  principal of TSP. Mr. and Mrs.  Paluck possess shared power to vote and to
direct the  disposition  of those  Shares  held in their  respective  names.  In





addition,  Mr.  Paluck  possesses  sole power to direct the  disposition  of the
securities held by the Managed Accounts. Thus, as of the Reporting Date, for the
purposes of Reg. Section 240.13d-3, (i) Mr. Paluck may be deemed to beneficially
own  7,632,346  Shares or 10.3% of the Shares issued and  outstanding  as of the
Reporting Date, and (ii) Mrs. Paluck may be deemed to beneficially own 1,000,000
Shares or 1.3% of the Shares issued and  outstanding  as of the Reporting  Date.
Each of the reporting persons hereby expressly disclaims membership in a "group"
under Section  13(d) of the Act and the rules and  regulations  thereunder  with
respect to the Shares  reported  herein,  and this  Schedule  13G/A shall not be
deemed to be an admission that any such  reporting  person is a member of such a
group.  THIS SCHEDULE  13G/A SETS FORTH THAT THOMAS S. PALUCK AND DOROTHY PALUCK
ARE THE REPORTING PERSONS FOR THE SECURITIES REPORTED HEREIN AS OF THE REPORTING
DATE.  CONCURRENTLY  WITH THE FILING OF THIS SCHEDULE  13G/A WITH THE SECURITIES
AND  EXCHANGE  COMMISSION  (THE  "SEC"),  MR.  AND MRS. PALUCK  HAVE  CAUSED  AN
AMENDMENT TO SCHEDULE 13G TO BE FILED ON BEHALF OF TSP WHICH FURTHER  AMENDS AND
RESTATES  THE  SCHEDULE  13G FILED WITH THE SEC ON  JAUNUARY  16, 2008 UNDER THE
CENTRAL INDEX KEY FOR TSP (AS PREVIOUSLY  AMENDED,  THE "PRIOR 13G") AND REPORTS
THAT MR. AND MRS. PALUCK ARE THE REPORTING  PERSONS FOR THE SECURITIES  REPORTED
IN THE PRIOR 13G.







CUSIP No.  053491106
--------------------------------------------------------------------------------

(1)  Names of Reporting Persons.   I.R.S.  Identification  Nos. of Above Persons
     (entities only):

      Dorothy Paluck
--------------------------------------------------------------------------------

(2)  Check the Appropriate Box if a Member of a Group (See Instructions)
        (a) [ ]
        (b) [X]
--------------------------------------------------------------------------------

(3)     SEC Use Only
--------------------------------------------------------------------------------

(4)     Citizenship or Place of Organization:  United States
--------------------------------------------------------------------------------
Number of Shares Beneficially Owned
  by Each Reporting Person            (5) Sole Voting Power:                  0*
                                          --------------------------------------
                                      (6) Shared Voting Power:        1,000,000*
                                          --------------------------------------
                                      (7) Sole Dispositive Power:             0*
                                          --------------------------------------
                                      (8) Shared Dispositive Power:   1,000,000*
                                          --------------------------------------
--------------------------------------------------------------------------------
 (9) Aggregate Amount Beneficially Owned by Each Reporting Person:

            1,000,000*
--------------------------------------------------------------------------------

(10) Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See
     Instructions):   [ ]
--------------------------------------------------------------------------------

(11) Percent of Class Represented by Amount in Row (9):  1.3%*
--------------------------------------------------------------------------------

(12) Type of Reporting Person (See Instructions):  IN
--------------------------------------------------------------------------------
* Based on information  set forth on the Form 10-Q of AVANT  Immunotherapeutics,
Inc. (the  "Company") as filed with the  Securities  and Exchange  Commission on
November 7, 2007, there were 74,188,066 shares of common stock, par value $0.001
per share (the  "Shares"),  of the Company issued and outstanding as of November
5, 2007.  As of December 31, 2007 (the  "Reporting Date"),  Thomas S. Paluck and
Dorothy Paluck held 770,000 and 230,000 Shares, respectively. In addition, as of
the Reporting  Date, TSP Capital  Management  Group,  LLC ("TSP") managed one or
more private  investment  accounts on behalf of various  clients  (the  "Managed
Accounts"),  which owned in the aggregate  6,632,346  Shares.  Mr. Paluck is the
sole  principal of TSP.  Mr. and Mrs. Paluck possess shared power to vote and to
direct the  disposition  of those  Shares  held in their  respective  names.  In





addition,  Mr.  Paluck  possesses  sole power to direct the  disposition  of the
securities held by the Managed Accounts. Thus, as of the Reporting Date, for the
purposes of Reg. Section 240.13d-3, (i) Mr. Paluck may be deemed to beneficially
own  7,632,346  Shares or 10.3% of the Shares issued and  outstanding  as of the
Reporting Date, and (ii) Mrs. Paluck may be deemed to beneficially own 1,000,000
Shares or 1.3% of the Shares issued and  outstanding  as of the Reporting  Date.
Each of the reporting persons hereby expressly disclaims membership in a "group"
under Section  13(d) of the Act and the rules and  regulations  thereunder  with
respect to the Shares  reported  herein,  and this  Schedule  13G/A shall not be
deemed to be an admission that any such  reporting  person is a member of such a
group.  THIS SCHEDULE  13G/A SETS FORTH THAT THOMAS S. PALUCK AND DOROTHY PALUCK
ARE THE REPORTING PERSONS FOR THE SECURITIES REPORTED HEREIN AS OF THE REPORTING
DATE.  CONCURRENTLY  WITH THE FILING OF THIS SCHEDULE  13G/A WITH THE SECURITIES
AND  EXCHANGE  COMMISSION  (THE  "SEC"),  MR.  AND MRS. PALUCK  HAVE  CAUSED  AN
AMENDMENT TO SCHEDULE 13G TO BE FILED ON BEHALF OF TSP WHICH FURTHER  AMENDS AND
RESTATES  THE  SCHEDULE  13G FILED WITH THE SEC ON  JAUNUARY  16, 2008 UNDER THE
CENTRAL INDEX KEY FOR TSP (AS PREVIOUSLY  AMENDED,  THE "PRIOR 13G") AND REPORTS
THAT MR. AND MRS. PALUCK ARE THE REPORTING  PERSONS FOR THE SECURITIES  REPORTED
IN THE PRIOR 13G.








THIS SCHEDULE  13G/A SETS FORTH THAT THOMAS S. PALUCK AND DOROTHY PALUCK ARE THE
REPORTING  PERSONS FOR THE SECURITIES  REPORTED HEREIN AS OF THE REPORTING DATE.
CONCURRENTLY  WITH THE FILING OF THIS  SCHEDULE  13G/A WITH THE  SECURITIES  AND
EXCHANGE COMMISSION (THE "SEC"), MR. AND MRS. PALUCK HAVE CAUSED AN AMENDMENT TO
SCHEDULE 13G TO BE FILED ON BEHALF OF TSP WHICH FURTHER  AMENDS AND RESTATES THE
SCHEDULE 13G FILED WITH THE SEC ON JAUNUARY 16, 2008 UNDER THE CENTRAL INDEX KEY
FOR TSP (AS PREVIOUSLY  AMENDED,  THE "PRIOR 13G") AND REPORTS THAT MR. AND MRS.
PALUCK ARE THE REPORTING PERSONS FOR THE SECURITIES REPORTED IN THE PRIOR 13G.


Item 1(a).  Name Of Issuer:  AVANT Immunotherapeutics, Inc.

Item 1(b).  Address of Issuer's Principal Executive Offices:

            119 Fourth Avenue
            Needham, MA 02494

Item 2(a).  Name of Person Filing:

            Thomas S. Paluck
            Dorothy Paluck

Item 2(b).  Address of Principal Business Office or, if None, Residence:

            TSP Capital Management Group, LLC
            382 Springfield Avenue, Suite 500
            Summit, NJ 07901

Item 2(c).  Citizenship

            Thomas S. Paluck:   United States
            Dorothy Paluck:     United States

Item 2(d).  Title of Class of Securities:  Common Stock, par value $0.001 per
            share

Item 2(e).  CUSIP No.:   053491106

Item 3.     If This Statement Is Filed Pursuant to Sections 240.13d-1(b) or
            240.13d-2(b) or (c), check whether the Person Filing is a:

            Not applicable.

Item 4.  Ownership:

         (a) Amount Beneficially Owned
             Thomas S. Paluck:              7,632,346*
             Dorothy Paluck:                1,000,000*

         (b) Percent of Class
             Thomas S. Paluck:                  10.3%*
             Dorothy Paluck:                     1.3%*


* Based on information  set forth on the Form 10-Q of AVANT  Immunotherapeutics,
Inc. (the  "Company") as filed with the  Securities  and Exchange  Commission on
November 7, 2007, there were 74,188,066 shares of common stock, par value $0.001
per share (the  "Shares"),  of the Company issued and outstanding as of November
5, 2007. As of December 31, 2007 (the  "Reporting  Date"),  Thomas S. Paluck and
Dorothy Paluck held 770,000 and 230,000 Shares, respectively. In addition, as of
the Reporting  Date, TSP Capital  Management  Group,  LLC ("TSP") managed one or
more private  investment  accounts on behalf of various  clients  (the  "Managed
Accounts"),  which owned in the aggregate  6,632,346  Shares.  Mr. Paluck is the
sole  principal of TSP.  Mr. and Mrs. Paluck possess shared power to vote and to
direct the  disposition  of those  Shares  held in their  respective  names.  In
addition,  Mr. Paluck  possesses  sole  power to direct the  disposition  of the
securities held by the Managed Accounts. Thus, as of the Reporting Date, for the
purposes of Reg. Section 240.13d-3, (i) Mr. Paluck may be deemed to beneficially
own  7,632,346  Shares or 10.3% of the Shares issued and  outstanding  as of the
Reporting Date, and (ii) Mrs. Paluck may be deemed to beneficially own 1,000,000
Shares or 1.3% of the Shares issued and  outstanding  as of the Reporting  Date.
Each of the reporting persons hereby expressly disclaims membership in a "group"
under Section  13(d) of the Act and the rules and  regulations  thereunder  with
respect to the Shares  reported  herein,  and this  Schedule  13G/A shall not be
deemed to be an admission that any such  reporting  person is a member of such a
group.




         (c) Number of Shares as to which the person has:

             (i)  sole power to vote or to direct the vote
                  Thomas S. Paluck:                    0*
                  Dorothy Paluck:                      0*

             (ii) shared power to vote or to direct the vote
                  Thomas S. Paluck:            1,000,000*
                  Dorothy Paluck:              1,000,000*

            (iii) sole power to dispose or to direct the disposition of
                  Thomas S. Paluck:            6,632,346*
                  Dorothy Paluck:                      0*

             (iv) shared power to dispose or to direct the disposition of
                  Thomas S. Paluck:            1,000,000*
                  Dorothy Paluck:              1,000,000*



Item 5.  Ownership of Five Percent or Less of a Class:

         Not applicable.


Item 6.  Ownership of More Than Five Percent on Behalf of Another Person:

         Not applicable.



* Based on information  set forth on the Form 10-Q of AVANT  Immunotherapeutics,
Inc. (the  "Company") as filed with the  Securities  and Exchange  Commission on
November 7, 2007, there were 74,188,066 shares of common stock, par value $0.001
per share (the  "Shares"),  of the Company issued and outstanding as of November
5, 2007. As of December 31, 2007 (the  "Reporting  Date"),  Thomas S. Paluck and
Dorothy Paluck held 770,000 and 230,000 Shares, respectively. In addition, as of
the Reporting  Date, TSP Capital  Management  Group,  LLC ("TSP") managed one or
more private  investment  accounts on behalf of various  clients  (the  "Managed
Accounts"),  which owned in the aggregate  6,632,346  Shares.  Mr. Paluck is the
sole  principal of TSP.  Mr. and Mrs. Paluck possess shared power to vote and to
direct the  disposition  of those  Shares  held in their  respective  names.  In
addition,  Mr. Paluck  possesses  sole power  to direct the  disposition  of the
securities held by the Managed Accounts. Thus, as of the Reporting Date, for the
purposes of Reg. Section 240.13d-3, (i) Mr. Paluck may be deemed to beneficially
own  7,632,346  Shares or 10.3% of the Shares issued and  outstanding  as of the
Reporting Date, and (ii) Mrs. Paluck may be deemed to beneficially own 1,000,000
Shares or 1.3% of the Shares issued and  outstanding  as of the Reporting  Date.
Each of the reporting persons hereby expressly disclaims membership in a "group"
under Section  13(d) of the Act and the rules and  regulations  thereunder  with
respect to the Shares  reported  herein,  and this  Schedule  13G/A shall not be
deemed to be an admission that any such  reporting  person is a member of such a
group.





Item 7.  Identification  and  Classification  of the  Subsidiary Which  Acquired
         the Securities:

         Not applicable.


Item 8.  Identification and Classification of Members of the Group:

         Not applicable.


Item 9.  Notice of Dissolution of Group:

         Not applicable.


Item 10.  Certification

          By  signing  below I certify  that,  to the best of my  knowledge  and
belief, the securities  referred to above were not acquired and are not held for
the purpose of or with the effect of changing or influencing  the control of the
issuer of the  securities  and were not acquired and are not held in  connection
with or as a participant in any transaction having that purpose or effect.






                                    SIGNATURE

          After reasonable inquiry and to the best of my  knowledge  and belief,
I certify that the information set forth in this statement is true, complete and
correct.


                                              February 26, 2008


                                              /s/ Thomas S. Paluck
                                              ----------------------------------
                                              Thomas S. Paluck


                                              /s/ Dorothy Paluck
                                              ----------------------------------
                                              Dorothy Paluck




      Attention:  Intentional misstatements or omissions of fact constitute
                Federal criminal violations (See 18 U.S.C. 1001)








                                                                       EXHIBIT 1


                             JOINT FILING AGREEMENT


In accordance with Rule 13G-1(k)  promulgated under the Securities  Exchange Act
of 1934, as amended, the persons named below agree to the joint filing on behalf
of each of them a Statement on Schedule 13G (including  amendments thereto) with
regard to the common stock of AVANT  Immunotherapeutics,  Inc. and further agree
that this  Joint  Filing  Agreement  be  included  as an  Exhibit  to such joint
filings.  In evidence thereof,  the undersigned,  being duly authorized,  hereby
execute this Joint Filing Agreement as of February 26, 2008.



                                              /s/ Thomas S. Paluck
                                              ----------------------------------
                                              Thomas S. Paluck


                                              /s/ Dorothy Paluck
                                              ----------------------------------
                                              Dorothy Paluck