PROSPECTUS SUPPLEMENT                             Filed Pursuant to 424(b)(2)
(To Prospectus dated May 2, 2006)                 Registration No. 333-133482


                                  DryShips Inc.

                          Up to 5,000,000 Common Shares


     We have  entered  into a  sales  agreement  with  Cantor  Fitzgerald  & Co.
relating to the common  shares  offered by this  prospectus  supplement  and the
accompanying  prospectus  dated May 2, 2006. In accordance with the terms of the
sales  agreement,  and  except  as  noted  below,  we may  offer  and sell up to
5,000,000  of our common  shares,  $0.01 par value per share,  from time to time
through  Cantor  Fitzgerald  & Co.,  as our  agent for the offer and sale of the
common shares.

     Our common shares are listed on The Nasdaq National Market under the symbol
"DRYS." The last reported sale price of our common shares on The Nasdaq National
Market on May 8, 2006 was $10.04 per share.

     Sales of our common shares,  if any, under this  prospectus  supplement and
the  accompanying  prospectus may be made in sales deemed to be  "at-the-market"
equity offerings as defined in Rule 415 promulgated  under the Securities Act of
1933,  as  amended,  including  sales made  directly  on or  through  The Nasdaq
National Market, the exisitng trading market for our common stock, sales made to
or through a market maker other than on an exchange or otherwise,  in negotiated
transactions  at  market  prices  prevailing  at the  time of sale or at  prices
related to such  prevailing  market prices and/or any other method  permitted by
law.

     Cantor Fitzgerald & Co. will be entitled to compensation  equal to 2.50% of
the gross proceeds of the sale of any of the 5,000,000 common shares  referenced
herein  that  are  sold in  "at-the-market"  offerings,  and  4.0% of the  gross
proceeds  of the sale of any of those  shares  in  negotiated  transactions.  In
connection with the sale of the common shares on our behalf, Cantor Fitzgerald &
Co. may be deemed to be an  "underwriter"  within the meaning of the  Securities
Act of 1933, as amended,  and the compensation of Cantor Fitzgerald & Co. may be
deemed to be underwriting commissions or discounts.

     Investing  in our common  shares  involves  risks.  See the risk factors in
beginning on page 5 of the  accompanying  prospectus to read about the risks you
should consider before purchasing our common shares.

     Neither the  Securities and Exchange  Commission  nor any state  securities
commission has approved or  disapproved  of these  securities or passed upon the
adequacy  or  accuracy  of  this  prospectus   supplement  or  the  accompanying
prospectus. Any representation to the contrary is a criminal offense.

                             Cantor Fitzgerald & Co.

             The date of this prospectus supplement is May 10, 2006





                               PROSPECTUS SUMMARY

     Unless  the  context  otherwise  requires,   as  used  in  this  prospectus
supplement,  the terms  "Company,"  "we," "us," and "our" refer to DryShips Inc.
and all of its subsidiaries.

     We use the term deadweight, or dwt, in describing the size of vessels. Dwt,
expressed in metric tons each of which is equivalent to 1,000 kilograms,  refers
to the maximum weight of cargo and supplies that a vessel can carry.

Our Company

     On April 19, 2006, we took delivery of m.v. Hille Oldendorff, a 2005 built,
55,566 dwt Handymax drybulk carrier.

     On April 20,  2006,  we entered  into a  Memorandum  of  Agreement  for the
purchase of the m.v. Atacama 2001 built, 75,941 dwt Panamax drybulk carrier. The
vessel will be renamed Maganari.

     Following the delivery of the Atacama,  our fleet of 29 vessels consists of
four Capesize drybulk  carriers,  22 Panamax drybulk carriers and three Handymax
drybulk carriers.

                                 CAPITALIZATION

     The following table sets forth our consolidated  capitalization at December
31, 2005:

     o    on an actual basis;

     o    on an adjusted  basis to give effect to (i) the  aggregate  payment of
          $12.1 million of dividends in January 2006 and April 2006 (declared in
          January 2006 and April 2006, respectively),  (ii) the payment of $30.4
          million in accordance  with the loan  repayment  schedule of the loans
          outstanding  at December  31,  2005 and (iii) the  drawdown of $ 553.3
          million  (gross  of  unamortized  deferred  financing  costs  of  $2.4
          million) under our new senior secured credit  facility of up to $628.7
          million which was used to repay $498.0  million  (gross of unamortized
          deferred  financing costs of $3.0 million) of  indebtedness  under our
          previous credit  facilities,  to fund a portion ($26.7 million) of the
          purchase  price of the Hille  Oldendorff  which was delivered on April
          19, 2006 and for working capital purposes;

     o    on a further  adjusted basis giving effect to our issuance and sale of
          5,000,000  shares  of  common  stock in this  offering  at an  assumed
          offering price of $10.04 per share, the last reported closing price of
          our  common  shares  on May 8,  2006,  net of  issuance  costs of $2.3
          million.


                                                                       As of December 31, 2005
                                                                                                  As Further
                                                         Actual           As Adjusted (1)        Adjusted (2)
                                                     ----------------    ------------------    ------------------
                                                                   (in thousands of U.S. dollars)
                                                                                              
Debt:
Current portion of long term debt                         $  107,738             $  35,820             $  35,820
Total long term debt, net of current portion                 417,615               515,069               515,069
                                                     ----------------    ------------------    ------------------
Total debt                                                   525,353               550,889               550,889
                                                     ----------------    ------------------    ------------------

Stockholders' equity:
Preferred stock, $0.01 par value; 30,000,000
shares authorized, none issued                                     -                     -                     -
Common stock, $0.01 par value; 45,000,000
shares authorized; 30,350,000 shares issued
and outstanding at December 31, 2005                             304                   304                   354
Additional paid-in capital                                   264,600               264,600               312,492
Retained earnings                                             91,597                79,457                79,457
                                                     ----------------    ------------------    ------------------
Total stockholders' equity                                   356,501               344,361               392,303
                                                     ----------------    ------------------    ------------------

Total capitalization                                      $  881,854            $  895,250            $  943,192
                                                     ================    ==================    ==================


-------------------
(1)  There have been no significant changes to our capitalization since December
     31, 2005, as so adjusted.

(2)  Assumes  a sale  price of $10.04  per  share,  which was the last  reported
     closing price of our common  shares on May 8, 2006.  Actual sale prices may
     differ.


                                    EXPENSES

     The following are the estimated  expenses of the issuance and  distribution
of the  securities  registered  under the  Registration  Statement of which this
prospectus supplement forms a part, all of which will be paid by us.

                        SEC registration fee                           $ 16,050
                                                                       --------
                        NASD Fee                                       $ 15,500
                                                                       --------
                        Legal fees and expenses                        $150,000
                                                                       --------
                        Accounting fees and expenses                   $ 59,500
                                                                       --------
                        Miscellaneous                                  $  8,950
                                                                       --------
                        Total                                          $250,000
                                                                       =========

23113 0002 668997