UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13G

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934

                               (AMENDMENT NO. 1)*


                          AEOLUS PHARMACEUTICALS, INC.
--------------------------------------------------------------------------------
                                (Name of Issuer)


                                  COMMON STOCK
--------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                  45325 S-10-1
--------------------------------------------------------------------------------
                                 (CUSIP Number)


                                DECEMBER 31, 2005
--------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

[ ]  Rule 13d-1(b)

[X]  Rule 13d-1(c)

[ ]  Rule 13d-1(d)


------------------
*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                                       1




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CUSIP No.                           13G                     Page 2 of 12 Pages
------------                                                --------------------

    1.      NAMES OF REPORTING PERSONS

            Great Point Partners, LLC

    2.      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

            (a) [ ]

            (b) [ ]


    3.      SEC USE ONLY

    4.      CITIZENSHIP OR PLACE OF ORGANIZATION

            USA
                                5.    SOLE VOTING POWER
      NUMBER OF SHARES
                                6.    SHARED VOTING POWER
   BENEFICIALLY OWNED BY EACH
                                                          1,600,000
      REPORTING PERSON
                                7.    SOLE DISPOSITIVE POWER
          WITH
                                8.    SHARED DISPOSITIVE POWER

                                                          1,600,000

    9.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                     1,600,000

   10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See
       Instructions)                                                      [  ]


   11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                     10.93%

   12. TYPE OF REPORTING PERSON (See Instructions)

                     OO






------------                                                --------------------
CUSIP No.                           13G                     Page 3 of 12 Pages
------------                                                --------------------
    1.      NAMES OF REPORTING PERSONS

            Biomedical Value Fund, L.P.

    2.      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

            (a)  [ ]

            (b)  [  ]


    3.      SEC USE ONLY

    4.      CITIZENSHIP OR PLACE OF ORGANIZATION

            Delaware, USA

                                5.    SOLE VOTING POWER
      NUMBER OF SHARES
                                6.    SHARED VOTING POWER
   BENEFICIALLY OWNED BY EACH
                                                          952,000
      REPORTING PERSON
                                7.    SOLE DISPOSITIVE POWER
          WITH
                                8.    SHARED DISPOSITIVE POWER

                                                          952,000

    9.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                     952,000

   10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See
Instructions)


   11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                     6.65%

   12. TYPE OF REPORTING PERSON (See Instructions)

                     PN




------------                                                --------------------
CUSIP No.                           13G                     Page 4 of 12 Pages
------------                                                --------------------


    1.      NAMES OF REPORTING PERSONS

            Great Point GP, LLC

    2.      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
            (a)  [ ]

            (b)  [  ]


    3.      SEC USE ONLY

    4.      CITIZENSHIP OR PLACE OF ORGANIZATION

            Delaware, USA

                                5.    SOLE VOTING POWER
      NUMBER OF SHARES

   BENEFICIALLY OWNED BY EACH   6.    SHARED VOTING POWER

      REPORTING PERSON                                    952,000

          WITH                  7.    SOLE DISPOSITIVE POWER


                                8     SHARED DISPOSITIVE POWER

                                                          952,000

    9.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                     952,000

   10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See
       Instructions)                                                         [ ]

   11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                     6.65%

   12. TYPE OF REPORTING PERSON (See Instructions)

                     OO






------------                                                --------------------
CUSIP No.                           13G                     Page 5 of 12 Pages
------------                                                --------------------


    1.      NAMES OF REPORTING PERSONS

            Biomedical Offshore Value Fund, Ltd.

    2.      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
            (a)  [ ]

            (b)  [ ]


    3.      SEC USE ONLY

    4.      CITIZENSHIP OR PLACE OF ORGANIZATION

            Cayman Islands

                                5.    SOLE VOTING POWER
    NUMBER OF SHARES
                                6.    SHARED VOTING POWER
 BENEFICIALLY OWNED BY EACH                               648,000
                                7.    SOLE DISPOSITIVE POWER
    REPORTING PERSON

           WITH                 8.    SHARED DISPOSITIVE POWER
                                                          648,000

    9.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                     648,000

   10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See
       Instructions)                                                         [ ]


   11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                     4.51%

   12. TYPE OF REPORTING PERSON (See Instructions)

                     CO






------------                                                --------------------
CUSIP No.                           13G                     Page 6 of 12 Pages
------------                                                --------------------



    1.      NAMES OF REPORTING PERSONS

            Dr. Jeffrey R. Jay, M.D.

    2.      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
            (a)  [ ]

            (b)  [ ]

    3.      SEC USE ONLY

    4.      CITIZENSHIP OR PLACE OF ORGANIZATION

            Delaware, USA

                                5.    SOLE VOTING POWER
    NUMBER OF SHARES
                                6.    SHARED VOTING POWER
 BENEFICIALLY OWNED BY EACH
                                                          1,600,000
    REPORTING PERSON            7.    SOLE DISPOSITIVE POWER

           WITH
                                8.    SHARED DISPOSITIVE POWER
                                                          1,600,000

    9.      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                     1,600,000

   10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See
       Instructions)                                                         [ ]

   11.      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

                     10.93%

   12. TYPE OF REPORTING PERSON (See Instructions)

                     IN





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CUSIP No.                           13G                     Page 7 of 12 Pages
------------                                                --------------------


     ITEM 1.        NAMES OF REPORTING PERSONS

                    (a)      Aeolus Pharmaceuticals, Inc.

                    (b)      23811 Inverness Place
                             Laguna Niguel, California 92677
                             U.S.A.

     ITEM 2.

                    (a)      Name of Person Filing
                                Great Point Partners, LLC
                                Biomedical Value Fund, L.P.
                                Great Point GP, LLC
                                Biomedical Offshore Value Fund, Ltd.
                                Dr. Jeffrey R. Jay, M.D.

                    (b)      Address of Principal Business Office, or if none,
                             Residence
                                2 Pickwick Plaza
                                Suite 450
                                Greenwich, CT  06830

                    (c)      Citizenship

                    Great Point Partners, LLC is a limited liability company
                    organized under the laws of the State of Delaware.
                    Biomedical Value Fund, L.P. is a limited partnership
                    organized under the laws of the State of Delaware. Great
                    Point GP, LLC is a limited liability company organized under
                    the laws of the State of Delaware. Biomedical Offshore Value
                    Fund, Ltd. is a limited liability corporation organized
                    under the laws of the Cayman Islands. Dr. Jeffrey R. Jay,
                    M.D. is a citizen of the United States.

                    (d)      Title of Class of Securities

                             Common Stock

                    (e)      CUSIP Number

                             45325 S-10-1

     ITEM 3.        IF THIS  STATEMENT IS FILED PURSUANT TO  SS.240.13D-1(B)  OR
                    240.13D.2(B) OR (C), CHECK WHETHER THE PERSON FILING IS A:

                             Not Applicable.

                    (a)  [ ]    Broker or dealer registered under Section 15 of
                                the Act (15 U.S.C. 78o)

                    (b)  [ ]    Bank as defined in Section 3(a)(6) of the Act
                                (15 U.S.C. 78c).

                    (c)  [ ]    Insurance company as defined in Section 3(a)(19)
                                of the Act (15. U.S.C. 78c).

                    (d)  [ ]    Investment Company registered under Section 8 of
                                the Investment Company Act of 1940
                                (15 U.S.C. 80a-8).

                    (e)  [ ]    An investment adviser in accordance with
                                ss.240.13d-1(b)(1)(ii)(E).

                    (f)  [ ]    An employee benefit plan or endowment fund in
                                accordance with ss.240.13d-1(b)(1)(ii)(F).



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CUSIP No.                           13G                     Page 8 of 12 Pages
------------                                                --------------------

                    (g)  [ ]    A parent holding company or control person in
                                accordance with ss.240.13d-1(b)(1)(ii)(G).

                    (h)  [ ]    A savings associations as defined in Section
                                3(b) of the Federal Deposit Insurance Act (12
                                U.S.C. 1813).

                    (i)  [ ]    A church plan that is excluded from the
                                definition of an investment company under
                                Section 3(c)(14) of the Investment Company Act
                                of 1940 (15 U.S.C. 80a-3).

                    (j)  [ ]    Group, in accordance with
                                ss.240.13d-1(b)(1)(ii)(J).




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CUSIP No.                           13G                     Page 9 of 12 Pages
------------                                                --------------------

     ITEM 4.        OWNERSHIP

                    Biomedical Value Fund, L.P. ("BVF") is the direct beneficial
                    owner of 952,000 shares (the "BVF Shares"), consisting of
                    680,000 shares of Common Stock and warrants to purchase
                    272,000 shares of Common Stock. Great Point GP, LLC, is the
                    general partner of BVF, and by virtue of such status may be
                    deemed to be the beneficial owner of the BVF Shares. Great
                    Point Partners, LLC is the investment manager of BVF, and by
                    virtue of such status may be deemed to be the beneficial
                    owner of the BVF Shares. Dr. Jeffrey R. Jay, M.D. has voting
                    and investment power with respect to the BVF Shares, and
                    therefore may be deemed to be the beneficial owner of the
                    BVF Shares.

                    Biomedical Offshore Value Fund, Ltd. ("BOVF") is the direct
                    beneficial owner of 648,000 shares (the "BOVF Shares"),
                    consisting of 320,000 shares of Common Stock, warrants to
                    purchase 228,000 shares of Common Stock, and preferred stock
                    convertible into 100,000 shares of Common Stock. Great Point
                    Partners, LLC is the investment manager of BOVF, and by
                    virtue of such status may be deemed to be the beneficial
                    owner of the BOVF Shares. Dr. Jeffrey R. Jay, M.D. has
                    voting and investment power with respect to the BOVF Shares,
                    and therefore may be deemed to be the beneficial owner of
                    the BOVF Shares.

                    Notwithstanding the above, Great Point Partners, LLC and Dr.
                    Jay disclaim beneficial ownership of the BVF Shares and the
                    BOVF Shares and Great Point GP, LLC disclaims beneficial
                    ownership of the BVF Shares, except to the extent of their
                    respective pecuniary interests.


                    The Information in Items 1 and 5 through 11 on the cover
                    pages of this Amendment No. 1 to Schedule 13G is hereby
                    incorporated by reference.

                    Provide the following information regarding the aggregate
                    number and percentage of the class of securities of the
                    issuer identified in Item 1.

                    (a) Amount beneficially owned: ______________________.

                    (b) Percent of class: ______________________.

                    (c) Number of shares as to which the person has:

                             (i)   Sole power to vote or to direct the vote
                                   ______________________.

                             (ii)  Shared power to vote or to direct the vote
                                   ______________________.

                             (iii) Sole power to dispose or to direct the
                                   disposition of ______________________.

                             (iv)  Shared power to dispose or to direct the
                                   disposition of ______________________.

ITEM 5.           OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

                  Not Applicable.

ITEM 6.           OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER
                  PERSON:

                  Not Applicable.

ITEM 7.           IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
                  ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING
                  COMPANY



------------                                                --------------------
CUSIP No.                           13G                     Page 10 of 12 Pages
------------                                                --------------------

                  Not Applicable.

ITEM 8.           IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

                  Not Applicable.

ITEM 9.           NOTICE OF DISSOLUTION OF GROUP

                  Not Applicable.

ITEM 10.          CERTIFICATION

By signing below I certify that, to the best of my knowledge and belief, the
securities referred to above were not acquired and are not held for the purpose
of or with the effect of changing or influencing the control of the issuer of
the securities and were not acquired and are not held in connection with or as
participant in any transaction having that purpose or effect.




------------                                                --------------------
CUSIP No.                           13G                     Page 11 of 12 Pages
------------                                                --------------------


                                    SIGNATURE

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Date:  February 13, 2006

                BIOMEDICAL VALUE FUND, L.P.


                Signature:        /s/ Dr. Jeffrey R. Jay, M.d.
                                  --------------------------------------------
                                  By Great Point GP, LLC,
                                    as general partner,
                                  By Dr. Jeffrey R. Jay, M.D.,
                                    as senior managing member

                GREAT POINT GP, LLC


                Signature:        /s/ Dr. Jeffrey R. Jay, M.d.
                                  --------------------------------------------
                                  By Dr. Jeffrey R. Jay, M.D.
                                    as senior managing member

                BIOMEDICAL OFFSHORE VALUE FUND, LTD.


                Signature:        /s/ Dr. Jeffrey R. Jay, M.d.
                                  --------------------------------------------
                                  By Great Point Partners, LLC,
                                    as investment manager,
                                  By Dr. Jeffrey R. Jay, M.D.,
                                    as senior managing member

                GREAT POINT PARTNERS, LLC


                Signature:        /s/ Dr. Jeffrey R. Jay, M.d.
                                  --------------------------------------------
                                  By Dr. Jeffrey R. Jay, M.D.,
                                    as senior managing member

                DR. JEFFREY R. JAY, M.D.

                Signature:        /s/ Dr. Jeffrey R. Jay, M.d.
                                  --------------------------------------------







                                                                       EXHIBIT A

              AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE 13G


The undersigned hereby agree as follows:

         (i) Each of them is individually eligible to use the Schedule 13G to
which this Exhibit is attached, and such Schedule 13G is filed on behalf of each
of them; and

         (ii) Each of them is responsible for the timely filing of such Schedule
13G and any amendments thereto, and for the completeness and accuracy of the
information concerning such person contained therein; but none of them is
responsible for the completeness or accuracy of the information concerning the
other persons making the filing, unless such person knows or has reason to
believe that such information is inaccurate.

Date:  February 13, 2006

              BIOMEDICAL VALUE FUND, L.P.


              Signature:        /s/ Dr. Jeffrey R. Jay, M.d.
                                --------------------------------------------
                                By Great Point GP, LLC,
                                  as general partner,
                                By Dr. Jeffrey R. Jay, M.D.,
                                  as senior managing member

              GREAT POINT GP, LLC


              Signature:        /s/ Dr. Jeffrey R. Jay, M.d.
                                --------------------------------------------
                                By Dr. Jeffrey R. Jay, M.D.
                                  as senior managing member

              BIOMEDICAL OFFSHORE VALUE FUND, LTD.


              Signature:        /s/ Dr. Jeffrey R. Jay, M.d.
                                --------------------------------------------
                                By Great Point Partners, LLC,
                                  as investment manager,
                                By Dr. Jeffrey R. Jay, M.D.,
                                  as senior managing member

              GREAT POINT PARTNERS, LLC


              Signature:        /s/ Dr. Jeffrey R. Jay, M.d.
                                --------------------------------------------
                                By Dr. Jeffrey R. Jay, M.D.,
                                  as senior managing member

              DR. JEFFREY R. JAY, M.D.

              Signature:        /s/ Dr. Jeffrey R. Jay, M.d.
                                --------------------------------------------