Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0287
Expires: January 31, 2005
Estimated average burden hours per response... 0.5

(Print or Type Responses)
1. Name and Address of Reporting Person *
PEARL FRANK H
  2. Issuer Name and Ticker or Trading Symbol
BIOENVISION INC [BIVN]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) __X__ Other (specify below)
See Footnotes (3) and (4)
(Last)
(First)
(Middle)
2099 PENNSYLVANIA AVENUE, SUITE 900
3. Date of Earliest Transaction (Month/Day/Year)
12/22/2004
(Street)

WASHINGTON, DC 20006-1813
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock, $0.001 par value ("Common Stock") 12/22/2004   S   31 (1) D $ 8.52 396,758 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   35 (2) D $ 8.52 396,723 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   46 (1) D $ 8.53 396,677 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   52 (2) D $ 8.53 396,625 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   230 (1) D $ 8.54 396,395 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   261 (2) D $ 8.54 396,134 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   782 (1) D $ 8.55 395,352 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   889 (2) D $ 8.55 394,463 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   296 (1) D $ 8.57 394,167 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   337 (2) D $ 8.57 393,830 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   383 (1) D $ 8.58 393,447 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   436 (2) D $ 8.58 393,011 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   6,181 (1) D $ 8.6 386,830 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   7,021 (2) D $ 8.6 379,809 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   31 (1) D $ 8.61 379,778 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   35 (2) D $ 8.61 379,743 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   113 (1) D $ 8.62 379,630 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   129 (2) D $ 8.62 379,501 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   76 (1) D $ 8.63 379,425 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   86 (2) D $ 8.63 379,339 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   153 (1) D $ 8.65 379,186 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   174 (2) D $ 8.65 379,012 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   552 (1) D $ 8.67 378,460 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   627 (2) D $ 8.67 377,833 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   261 (1) D $ 8.69 377,572 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   296 (2) D $ 8.69 377,276 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   1,045 (1) D $ 8.7 376,231 I See Footnotes (3) (4)
Common Stock 12/22/2004   S   1,187 (2) D $ 8.7 375,044 I See Footnotes (3) (4)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
PEARL FRANK H
2099 PENNSYLVANIA AVENUE
SUITE 900
WASHINGTON, DC 20006-1813
    X   See Footnotes (3) and (4)
PERSEUSPUR LLC
2099 PENNSYLVANIA AVE
SUITE 900
WASHINGTON, DC 20006-1813
    X   See Footnotes (3) and (4)

Signatures

 /s/ Rodd Macklin, Attorney-in-Fact for Frank H. Pearl (5)   12/23/2004
**Signature of Reporting Person Date

 /s/ Rodd Macklin, Secretary and Treasurer, Perseuspur, LLC   12/23/2004
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) These shares sold were held by Perseus BioTech Investment, LLC ("PBI").
(2) These shares sold were held by Perseus-Soros Partners, LLC, a Delaware limited liability company ("Perseus-Soros Partners").
(3) The securities reported herein are held for the account of Perseus-Soros BioPharmaceutical Fund, LP, a Delaware limited partnership ("Perseus-Soros"), Perseus-Soros Partners and PBI. Following the transaction reported herein and in the other Form 4's filed by the reporting persons on December 23, 2004, Perseus-Soros owns 375,044 shares, and Perseus-Soros Partners and PBI do not own any shares. Frank H. Pearl ("Mr. Pearl" ) and Perseuspur, LLC ("Perseuspur") (together, the "Reporting Persons") may be deemed to indirectly beneficially own the shares owned of record by Perseus-Soros, Perseus-Soros Partners and PBI.
(4) Pursuant to Rule 16a-1(a)(2)(ii)(B) under the Securities Exchange Act of 1934, as amended (the "Act"), Mr. Pearl and Perseuspur are deemed to be beneficial owners of the shares beneficially owned by Perseus-Soros, Perseus-Soros Partners or PBI only to the extent of the greater of his or its respective direct or indirect interest in the profits or capital account of Perseus-Soros, Perseus-Soros Partners or PBI. Pursuant to Rule 16a-1(a)(4) under the Act, this filing shall not be deemed an admission that Mr. Pearl or Perseuspur is, for purposes of Section 16 of the Act or otherwise, the beneficial owner of any securities owned by Perseus-Soros, Perseus-Soros Partners or PBI in excess of such amount.
 
Remarks:
(5) Mr. Macklin is signing in his capacity as Attorney-in-Fact for Frank H. Pearl. 


Form 1 of 2 Forms

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.