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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, DC. 20549
 
SCHEDULE 14A
(Rule 14A-101)
 
INFORMATION REQUIRED IN PROXY STATEMENT
SCHEDULE 14A INFORMATION
 
Proxy Statement Pursuant to Section 14(a) of
the Securities Exchange Act of 1934
 
Filed by the Registrant x
Filed by a Party other than the Registrant
Check the appropriate box:
o
Preliminary Proxy Statement
o
Confidential, for Use of the Commission Only
o
Definitive Proxy Statement
 
(as permitted by Rule 14a-6(e)(2))
x
Definitive Additional Materials
 
 
o
Soliciting Material Pursuant to Rule 14a-11(c)or Rule 14a-12
 
 
 
 
 
 LEXICON PHARMACEUTICALS, INC.
 (Name of Registrant as Specified In Its Charter)
 
(Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)
 
Payment of Filing Fee (Check the appropriate box):
 
x
No fee required.
o
Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11. 
 
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Title of each class of securities to which transaction applies:  N/A
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Aggregate number of securities to which transaction applies:  N/A
(3)    
Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is calculated and state how it was determined):  N/A 
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Total fee paid:  $0
 o
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Check box if any part of the fee is offset as provided by Exchange Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing.
 
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*** Exercise Your Right to Vote ***
 
 
Important Notice Regarding the Availability of Proxy Materials for the
 
 
Shareholder Meeting to be Held on April 28, 2011
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Meeting Information
 
 
 
 
 
 
 
 
Meeting Type:  
Annual Meeting
 
 
LEXICON PHARMACEUTICALS, INC.
 
For holders as of: February 28, 2011
 
 
 
 
 
 
 
 
Date:  April 28, 2011
Time:  8:00 AM CDT
 
 
 
 
 
 
 
 
Location:
Lexicon Pharmaceuticals, Inc.
 
 
 
 
 
 
 
 
 
8800 Technology Forest Place
 
 
 
 
 
 
 
 
 
The Woodlands, TX
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
You are receiving this communication because you hold shares in the above named company.
 
 
LEXICON PHARMACEUTICALS, INC.
8800 TECHNOLOGY FOREST PLACE
THE WOODLANDS, TX 77381
 
 
This is not a ballot. You cannot use this notice to vote these shares. This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. You may view the proxy materials online at www.proxyvote.com or easily request a paper copy (see reverse side)
 
 
 
 
 
 
 
 
 
 
 
We encourage you to access and review all of the important information contained in the proxy materials before voting
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
See the reverse side of this notice to obtain proxy materials and voting instructions
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
 

— BEFORE YOU VOTE —
How to Access the Proxy Materials
 
 
Proxy Materials Available to VIEW or RECEIVE:
1. Notice & Proxy Statement 2. Annual Report
How to View Online:
Have the information that is printed in the box marked by the arrow ‡ XXXX XXXX XXXX (located on the following page) and visit: www.proxyvote.com
How to Request and Receive a PAPER or E-MAIL Copy:
If you want to receive a paper or e-mail copy of these documents, you must request one. There is NO charge for requesting a copy. Please choose one of the following methods to make your request:
 
1) BY INTERNET:
www.proxyvote.com
 
2) BY TELEPHONE:
1-800-579-1639
 
3) BY EMAIL*:
sendmaterials@proxyvote.com
* If requesting materials by e-mail, please send a blank e-mail with the information that is printed in the box marked by the arrow ‡ XXXX XXXX XXXX (located on the following page) in the subject line.
 
Requests, instructions and other inquiries sent to this e-mail address will NOT be forwarded to your investment advisor. Please make the request as instructed above on or before April 14, 2011 to facilitate timely delivery.
 
  
 
— HOW TO VOTE —
 Please Choose One of The Following Voting Methods
 
Vote in Person:  Many shareholder meetings have attendance requirements including, but not limited to, the possession of an attendance ticket issued by the entity holding the meeting.  Please check the meeting materials for any special requirements for meeting attendance.  At the Meeting you will need to request a ballot to vote these shares.
 
Vote by Internet: To vote now by Internet, go to www.proxyvote.com.  Have the information that is printed in the box marked by the arrow ‡ XXXX XXXX XXXX available and follow the instructions.
 
 Vote by Mail:  You can vote by mail by requesting a paper copy of the materials, which will include a proxy card.
 

 
 

 
  Voting  items
 
 
The Board of Directors recommends that you vote FOR the following:
 
1.    
Election of Directors
 
Nominees:
 
01)  Samuel L. Barker, Ph.D.
02)  Christopher J. Sobecki
03) Judith L. Swain, M.D.
 
The Board of Directors recommends you vote FOR the following proposal:
 
4)    Advisory vote on the compensation paid to the Company's named executive officers
 
The Board of Directors recommends you vote for 1 YEAR on the following proposal:
 
5)    Advisory vote on the frequency of future advisory votes on the compensation paid to the Company's named executive officers
 
The Board of Directors recommends you vote FOR the following proposal:
 
6)    Ratification and approval of the appointment of Ernst & Young LLP as the Company's independent auditors for the fiscal year ending December 31, 2011
  
NOTE:  In their discretion, upon such other matters that may properly come before the meeting or any adjournment or adjournments thereof.