UNITED STATES SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549



                                    FORM 8-K


                                 Current Report

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934



   Date of report (Date of earliest event reported)     February 21, 2006
                                                       -------------------------

                                OPTION CARE, INC.
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             (Exact Name of Registrant as Specified in Its Charter)

          Delaware                       0-19878                36-3791193
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(State or Other Jurisdiction of        (Commission            (I.R.S. Employer
Incorporation)                         File Number)          Identification No.)

485 Half Day Road, Suite 300
Buffalo Grove, Illinois                                    60089
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(Address of Principal Executive Offices)                 (Zip Code)

                                 (847) 465-2100
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              (Registrant's Telephone Number, Including Area Code)

                                 Not Applicable
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          (Former Name or Former Address, if Changed Since Last Report)


     Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

[_]  Written communications pursuant to Rule 425 under the Securities
Act (17 CFR 230.425)

[_]  Soliciting material pursuant to Rule 14a-12 under the Exchange
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[_]  Pre-commencement communications pursuant to Rule 14d-2(b) under the
Exchange Act (17 CFR 240.14d-2(b))

[_]  Pre-commencement communications pursuant to Rule 13e-4(c) under the
Exchange Act (17 CFR 240.13e-4(c))





Item 2.02:  Results of Operations and Financial Condition.

     On February 21, 2006, Option Care, Inc. issued a press release announcing
financial results for its fiscal quarter and year ended December 31, 2005. The
full text of this press release is attached as Exhibit 99.1 to this Form 8-K and
is incorporated herein by reference.


Item 9.01:  Financial Statements and Exhibits.

(c)   Exhibits.

      99.1   Option Care Press Release dated February 21, 2006 regarding
             financial results for the quarter and year ended December 31, 2005.





                                   SIGNATURES
                                   ----------

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                      OPTION CARE, INC.

                                      By:   /s/ Paul Mastrapa
                                        ----------------------------------------
                                            Paul Mastrapa
                                            Senior Vice President and
                                            Chief Financial Officer

         Dated:  February 21, 2006