Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
LANDINE MICHAEL J
  2. Issuer Name and Ticker or Trading Symbol
ALKERMES INC [ALKS]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
SVP Corporate Development
(Last)
(First)
(Middle)
88 SIDNEY STREET
3. Date of Earliest Transaction (Month/Day/Year)
11/15/2007
(Street)

CAMBRIDGE, MA 02139
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Non-qualified stock option (right to buy) $ 16.69 11/15/2007   D(1)     56,036 10/28/2000 10/28/2009 Common Stock 56,036 $ 0 0 (1) D  
Non-qualified stock option (right to buy) $ 16.69 11/15/2007   A(2)   56,036     (3) 10/28/2009 Common Stock 56,036 $ 0 56,036 D  
Non-qualified stock option (right to buy) $ 29.31 11/15/2007   D(1)     66,589 11/20/2001 11/20/2010 Common Stock 66,589 $ 0 0 (1) D  
Non-qualified stock option (right to buy) $ 29.31 11/15/2007   A(2)   66,589     (3) 11/20/2010 Common Stock 66,589 $ 0 66,589 D  
Non-qualified stock option (right to buy) $ 19.4 11/15/2007   D(1)     15,465 10/02/2002 10/02/2011 Common Stock 15,465 $ 0 0 (1) D  
Non-qualified stock option (right to buy) $ 19.4 11/15/2007   A(2)   15,465     (3) 10/02/2011 Common Stock 15,465 $ 0 15,465 D  
Non-qualified stock option (right to buy) $ 14.57 11/15/2007   D(1)     30,625 10/17/2004 10/17/2013 Common Stock 30,625 $ 0 0 (1) D  
Non-qualified stock option (right to buy) $ 14.57 11/15/2007   A(2)   30,625     (3) 10/17/2013 Common Stock 30,625 $ 0 30,625 D  
Non-qualified stock option (right to buy) $ 14.9 11/15/2007   D(1)     61,861 12/17/2005 12/17/2014 Common Stock 61,861 $ 0 0 (1) D  
Non-qualified stock option (right to buy) $ 14.9 11/15/2007   A(2)   61,861     (4) 12/17/2014 Common Stock 61,861 $ 0 61,861 D  
Non-qualified stock option (right to buy) $ 18.6 11/15/2007   D(1)     28,374 12/09/2006 12/09/2015 Common Stock 28,374 $ 0 0 (1) D  
Non-qualified stock option (right to buy) $ 18.6 11/15/2007   A(2)   28,374     (5) 12/09/2015 Common Stock 28,374 $ 0 28,374 D  
Non-qualified stock option (right to buy) $ 20.79 11/15/2007   D(1)     12,657 05/02/2007 05/02/2016 Common Stock 12,657 $ 0 0 (1) D  
Non-qualified stock option (right to buy) $ 20.79 11/15/2007   A(2)   12,657     (6) 05/02/2016 Common Stock 12,657 $ 0 12,657 D  
Non-qualified stock option (right to buy) $ 14.38 11/15/2007   D(1)     29,145 12/12/2007 12/12/2016 Common Stock 29,145 $ 0 0 (1) D  
Non-qualified stock option (right to buy) $ 14.38 11/15/2007   A(2)   29,145     (7) 12/12/2016 Common Stock 29,145 $ 0 29,145 D  
Non-qualified stock option (right to buy) $ 15.95 11/15/2007   D(1)     15,000 06/01/2008 06/01/2017 Common Stock 15,000 $ 0 0 (1) D  
Non-qualified stock option (right to buy) $ 15.95 11/15/2007   A(2)   15,000     (8) 06/01/2017 Common Stock 15,000 $ 0 15,000 D  

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
LANDINE MICHAEL J
88 SIDNEY STREET
CAMBRIDGE, MA 02139
      SVP Corporate Development  

Signatures

 Jennifer Baptiste, Attorney-in-Fact for Michael J. Landine   11/19/2007
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Cancellation of non-qualified stock option by mutual agreement of Alkermes and the reporting person. As consideration for the cancellation, the reporting person was granted a new stock option under the Company's Amended and Restated 1999 Stock Option Plan with the same terms, including exercise price, vesting and number of shares, as the cancelled stock option.
(2) Re-grant of non-qualified stock option under the Amended and Restated 1999 Stock Option Plan as consideration for the cancellation of the non-qualified stock option. Re-granted non-qualified option has the same terms as the cancelled option, including exercise price, vesting and number of shares.
(3) Stock option vests in its entirety upon date of grant.
(4) Original Stock Option grant to which this relates included non-qualified stock options (set forth herein) and incentive stock options. Fifty percent (50%) of the Stock Option vests upon date of grant. The remainder of the Stock Option vests in equal annual installments on each of 12/17/2007 and 12/17/2008.
(5) Original Stock Option grant to which this relates included non-qualified stock options (set forth herein) and incentive stock options. Twenty-five percent (25%) of the Stock Option vests upon date of grant. The remainder of the Stock Option vests in equal annual installments on each of 12/9/2007, 12/9/2008 and 12/9/2009.
(6) Original Stock Option grant to which this relates included non-qualified stock options (set forth herein) and incentive stock options. Twenty-five (25%) of the Stock Option vests upon date of grant. The remainder of the Stock Option vests in equal annual installments on each of 5/2/2008, 5/2/2009 and 5/2/2010.
(7) Original Stock Option grant to which this relates included non-qualified stock options (set forth herein) and incentive stock options. The Stock Option vests in equal annual installments over a four-year period, at the rate of 25% per year commencing on 12/12/2007.
(8) Original Stock Option grant to which this relates included non-qualified stock options (set forth herein) and incentive stock options. The Stock Option vests in equal annual installments over a four-year period, at the rate of 25% per year commencing on 6/1/2008.

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