Developed with the bioactive leader’s proprietary AI, Forager® — Bio Gut Core joins the company’s growing portfolio of nature-derived, health ingredients and platform offerings
- Strong gut barrier function is the gateway to overall gut health. Providing a thriving environment for the gut microbiome, ensuring optimal nutrient absorption and filtering out toxic and undesirable elements are some of the key functions of a healthy gut barrier.
- A proprietary blend of two bioactives make up Bio Gut Core, N-trans caffeoyltyramine (NCT) and N-trans feruloyltyramine (NFT), which were found to deliver tangible digestive health benefits and improve gut barrier function in a double-blinded, randomized, placebo-controlled trial.
- Bio Gut Core delivers these clinically-backed bioactives to commercial customers in a ready-to-use, easy-to-formulate product offering.
- These results are the first of several clinical trial findings to be shared by Brightseed as the company plans to expand its commercial line of science-backed bioactive product offerings.
Today, Brightseed announced Bio Gut Core, a ready-to-use bioactive ingredient that delivers clinically-proven gut health benefits in low-dose, versatile ingredient applications. The launch coincides with the release of new human clinical trial data supporting the efficacy of Bio Gut Core to strengthen gut barrier function and promote digestive wellness within the study duration, three weeks, and for some subjects within one week of supplementation.
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Bio Gut Core was made possible by leveraging Brightseed’s Forager AI platform in the discovery of NCT and NFT, two bioactive compounds found in dozens of ubiquitous, natural plant sources.
The National Institutes of Health report that approximately 60 to 70 million Americans experience digestive conditions. Often overlooked, 88% of consumers report seeking products that restore gut barrier function per a representative survey of 2,000 American adults.
Gut barrier function is the missing link to total gut health and critically important for overall well being. The gut barrier acts like a protective shield in the digestive system, providing a thriving environment for the gut microbiome, ensuring optimal nutrient absorption, and keeping bad bacteria and toxins out of the bloodstream. A compromised gut barrier may lead to a “leaky gut,” which results from common factors like poor diet, stress, and environmental toxins. Leaky gut is associated with dysbiosis, inflammation, and poor nutrient absorption along with bloating, gas, diarrhea, and constipation. Until now, supplements targeting gut barrier function have required unfeasibly large doses while delivering questionable results.
Bio Gut Core brings together two clinically-proven bioactives in one product to enable a more complete digestive health product and enhance formulations that can effectively target the gut barrier. The beneficial effects include a reduction in symptoms associated with irritable bowel syndrome (IBS), which are similar to those observed in leaky gut, as well as relief from side effects related to GLP-1 medication use or exercise-induced permeability caused by prolonged strenuous exercise.
This breakthrough product was made possible by leveraging Brightseed’s Forager AI platform in the discovery of NCT and NFT, two bioactive compounds found in dozens of ubiquitous, natural plant sources like garlic and black pepper. These bioactives have the ability to activate HNF4⍺, a transcription factor shown to play a key role in gut barrier function and integrity. Therefore, HNF4⍺ agonists, NCT and NFT, have the potential to support a healthy gut barrier function as validated by this study.
In findings to be released from a double-blinded, randomized placebo-controlled trial recently completed by Brightseed, supplementation of NCT and NFT was found to significantly improve gut barrier function while reducing reported abdominal distention and pain in just three weeks. Testimonials from study participants further supported clinical findings:
“After about a week of taking the capsule [Bio Gut Core supplement], the difference was night and day. I had the best two weeks in a long time.”
“[Taking Bio Gut Core] has been absolutely life changing and has given me some quality of life back.”
“Not only are we introducing a novel, nature-derived ingredient to the $51 billion digestive market, with Bio Gut Core we’re delivering a next-level solution to provide relief for the tens of millions of Americans affected by debilitating digestive health conditions,” said Lee Chae, PhD, co-founder and CEO, Brightseed. “This gut health clinical data further validates the ability of Brightseed’s AI-driven discovery to meaningfully improve human health and quality of life. We have big plans from here.”
The human clinical study commissioned by Brightseed is currently under review and is anticipated to be published in a peer-review journal later this summer. Brightseed will be sharing findings from this study and more about the benefits of this new product at this year’s American Society for Nutrition NUTRITION 2025 Conference on May 31, 2025 in a session entitled, From Side Stream to Mainstream: How AI Discovered Bioactives Are Revolutionizing Gut & Metabolic Health Benefits in Consumer Goods.
“This study provides clinical proof that bioactives NCT and NFT significantly improve gut barrier function, delivering a much needed solution to health companies and consumers alike,” said Swati Kalgaonkar, Head of Medical & Scientific Affairs & Clinical Research at Brightseed. “Even more exciting than the clinical data from this study are the real-life experiences of study participants who have reported drastic improvements in quality of life and adverse symptom reduction. These kinds of outcomes are the reason Brightseed exists.”
To learn more about Bio Gut Core, view the product overview or request a sample now.
About Brightseed
Brightseed®, the bioactives company, is a World Economic Global Innovator that leverages AI discovery to illuminate nature-based solutions that elevate human health. Brightseed’s proprietary AI, Forager®, accelerates bioactive discovery, biological validation, and ingredient formulation from years to months, rapidly revealing new connections between nature and humanity. Brightseed produces clinically-proven bioactives for dietary supplements, food & beverage CPG, specialty nutrition, and medical foods to power proactive health worldwide. Learn more at brightseedbio.com.
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Even more exciting than the clinical data from this study are the real-life experiences of study participants who have reported drastic improvements in quality of life and adverse symptom reduction. These kinds of outcomes are the reason Brightseed exists.
Contacts
Media Contact
Nicki Briggs, MS, RDN
Communications, Brightseed
press@brightseedbio.com
